Systems Genetics

Methods and Protocols

  • Klaus Schughart
  • Robert W. Williams

Part of the Methods in Molecular Biology book series (MIMB, volume 1488)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Resources for Systems Genetics

    1. Front Matter
      Pages 1-1
    2. Robert W. Williams, Evan G. Williams
      Pages 3-29
    3. Leah C. Solberg Woods, Richard Mott
      Pages 31-44
  3. Tools for Analysis and Integration in Systems Genetics

    1. Front Matter
      Pages 45-45
    2. Janan T. Eppig, Cynthia L. Smith, Judith A. Blake, Martin Ringwald, James A. Kadin, Joel E. Richardson et al.
      Pages 47-73
    3. Megan K. Mulligan, Khyobeni Mozhui, Pjotr Prins, Robert W. Williams
      Pages 75-120
    4. Jason A. Bubier, Michael A. Langston, Erich J. Baker, Elissa J. Chesler
      Pages 131-152
    5. Martha Imprialou, Enrico Petretto, Leonardo Bottolo
      Pages 189-215
    6. Henrike Maatz, Sebastiaan van Heesch, Franziska Kreuchwig, Allison Faber, Eleonora Adami, Norbert Hubner et al.
      Pages 217-237
    7. Richard Green, Courtney Wilkins, Martin T. Ferris, Michael Gale Jr.
      Pages 251-263
    8. Karen Y. Oróstica, Ricardo A. Verdugo
      Pages 283-297
    9. Aida Moreno-Moral, Francesco Pesce, Jacques Behmoaras, Enrico Petretto
      Pages 337-362
  4. Systems Genetics Use Cases: Mapping and Combining Multiple Phenotypic Traits

    1. Front Matter
      Pages 363-363
    2. Patrick W. Keeley, Irene E. Whitney, Benjamin E. Reese
      Pages 365-390
    3. Sumana R. Chintalapudi, Monica M. Jablonski
      Pages 391-417
    4. Svitlana Podliesna, Connie R. Bezzina, Elisabeth M. Lodder
      Pages 431-454
    5. Rabea A. Hall, Frank Lammert
      Pages 455-466
    6. Gudrun A. Brockmann, Danny Arends, Sebastian Heise, Ayca Dogan
      Pages 481-497
    7. Maarten Loos, Matthijs Verhage, Sabine Spijker, August B. Smit
      Pages 519-530
    8. Aysar Nashef, Mahmoud Agbaria, Ariel Shusterman, Nicola Ivan Lorè, Alessandra Bragonzi, Ervin Wiess et al.
      Pages 551-578
  5. Back Matter
    Pages 607-609

About this book


This volume focuses on the use of system genetic methods and the use of murine models to study the role of gene variants and environmental factors on human health and disease—what is now often called personalized or precision health care. The protocols in this book will help readers analyze genetic causes of heritable variation across a wide range of systems and traits using rodent models. The chapters in this book are separated into three sections that cover: 1) resources for systems genetics; 2) tools for analysis and integration in systems genetics; and 3) systems genetics use cases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and tools, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and thorough, Systems Genetics: Methods and Protocols is a valuable resource for anyone who is interested in this diverse field.


Mendelian genetics phenotypes loci or gene variants QTL mapping metabolites protein sets of environmental factors and treatments mRNAs

Editors and affiliations

  • Klaus Schughart
    • 1
  • Robert W. Williams
    • 2
  1. 1.Department of Infection GeneticsHelmholtz Centre for Infection Research & University of Veterinary Medicine HannoverBraunschweigGermany
  2. 2.Department of Microbiology, Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2017
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-6425-3
  • Online ISBN 978-1-4939-6427-7
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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