© 2016

Antiepileptic Drug Discovery

Novel Approaches

  • Alan Talevi
  • Luisa Rocha
  • Explores novel approaches for the development of antiepileptic therapies to combat pharmacoresistance

  • Features practical guidance for the implementation of important protocols

  • Serves as an ideal source for medicinal chemists, pharmacologists, and other researchers working in the field


Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Novel Approaches for the Treatment of Epilepsy

    1. Front Matter
      Pages 1-1
    2. María-Leonor López-Meraz, Jesús-Servando Medel-Matus, Jerome Niquet
      Pages 3-22
    3. María Guadalupe Valle-Dorado, Laura Elena Córdova-Dávalos, Daniel Pérez-Pérez, Rosalinda Guevara-Guzmán, Luisa Rocha
      Pages 23-36
    4. Luciana Gavernet
      Pages 37-51
    5. Luz Adriana Pichardo-Macías, Itzel Jatziri Contreras-García, Sergio R. Zamudio, Edgar Mixcoha, Julieta G. Mendoza-Torreblanca
      Pages 53-81
    6. Cecilia Zavala-Tecuapetla, Luisa Rocha
      Pages 83-96
    7. Manola Cuéllar-Herrera, César E. Santana-Gómez, Francia Carmona-Cruz, Daruni Vázquez-Barrón, Francisco Velasco, Ana L. Velasco
      Pages 97-125
    8. Amalia Marelli, Liliana Czornyj, Luisa Rocha, Alberto Lazarowski
      Pages 147-161
    9. Karla G. Carvajal Aguilera, Bryan V. Phillips Farfán
      Pages 163-180
    10. Miguel A. López-García, Iris A. Feria-Romero, Julia J. Segura-Uribe, David Escalante-Santiago, Sandra Orozco-Suárez
      Pages 181-200
  3. Innovative Solutions for the Screening of New Antiepileptics Drugs and Addressing Multi-Drug Resistant Epilepsy

    1. Front Matter
      Pages 201-201
    2. Leonardo Lara-Valderrábano, Ivette Bañuelos-Cabrera, Víctor Navarrete-Modesto, Luisa Rocha
      Pages 203-219
    3. Gabriela Rogel-Salazar, Hiram Luna-Munguia
      Pages 221-236
    4. Manuel Couyoupetrou, Mauricio Di Ianni, Melisa Gantner, Guido Pesce, Roxana Peroni, Alan Talevi et al.
      Pages 259-279
    5. María E. Ruiz, Guillermo R. Castro
      Pages 299-326
  4. Potential Contributions of Network Pharmacology and Drug Repurposing in Antiepileptic Drug Discovery

    1. Front Matter
      Pages 327-327

About this book


This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. 

Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.


Antiepileptogenesis Epilepsy treatment Multi-drug resistance Network Pharmacology Drug repurposing Pharmaceutical screening Computer-aided approaches

Editors and affiliations

  • Alan Talevi
    • 1
  • Luisa Rocha
    • 2
  1. 1.Laboratorio de Investigación y Desarrollo de Bioactivos (LIDeB) Faculty of Exact SciencesNational University of La PlataLa PlataArgentina
  2. 2.Department of PharmacobiologyCenter for Research and Advanced StudiesMexico CityMexico

Bibliographic information

  • Book Title Antiepileptic Drug Discovery
  • Book Subtitle Novel Approaches
  • Editors Alan Talevi
    Luisa Rocha
  • Series Title Methods in Pharmacology and Toxicology
  • Series Abbreviated Title Meth.Pharmacology,Toxicology
  • DOI
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-1-4939-6353-9
  • Softcover ISBN 978-1-4939-8174-8
  • eBook ISBN 978-1-4939-6355-3
  • Series ISSN 1557-2153
  • Series E-ISSN 1940-6053
  • Edition Number 1
  • Number of Pages XI, 386
  • Number of Illustrations 9 b/w illustrations, 42 illustrations in colour
  • Topics Pharmacology/Toxicology
  • Buy this book on publisher's site
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