© 2016

Molecular and Cellular Mechanobiology

  • Shu Chien
  • Adam J. Engler
  • Peter Yingxiao Wang

Part of the Physiology in Health and Disease book series (PIHD)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Mechanosensors

    1. Front Matter
      Pages 1-1
    2. Li-Jing Chen, Wei-Li Wang, Jeng-Jiann Chiu
      Pages 29-56
    3. D. E. Leckband
      Pages 57-80
  3. Transducers

    1. Front Matter
      Pages 81-81
    2. Yubing Sun, Yue Shao, Xufeng Xue, Jianping Fu
      Pages 83-96
    3. Christopher A. McCulloch
      Pages 97-117
  4. Epigenetic and Genetic Regulations in the Nucleus

    1. Front Matter
      Pages 141-141
    2. Qin Peng, Binbin Cheng, Shaoying Lu, Shu Chien, Yingxiao Wang
      Pages 143-161
    3. Douglas Kelkhoff, Timothy Downing, Song Li
      Pages 163-173
    4. Jerome Irianto, Irena L. Ivanovska, Joe Swift, Dennis E. Discher
      Pages 175-195
    5. Yejun Wang, Ekta Makhija, Karthik Damodaran, G. V. Shivashankar
      Pages 197-216
  5. Applications

    1. Front Matter
      Pages 217-217
    2. Aileen Zhong, Craig A. Simmons
      Pages 255-276
    3. Laurent Fattet, Jing Yang
      Pages 277-290
  6. Back Matter
    Pages 291-302

About this book


This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.


Epigenetic regulation Genetic regulation Signal transduction cellular mechanobiology molecular mechanobiology

Editors and affiliations

  • Shu Chien
    • 1
  • Adam J. Engler
    • 2
  • Peter Yingxiao Wang
    • 3
  1. 1.Professor of Bioengineering and MedicineUniversity of California, San DiegoLa JollaUSA
  2. 2.Associate Professor of BioengineeringUniversity of California, San DiegoLa JollaUSA
  3. 3.Associate Professor of BioengineeringUniversity of California, San DiegoLa JollaUSA

Bibliographic information

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