Injury Models of the Central Nervous System

Methods and Protocols

  • Firas H. Kobeissy
  • C. Edward Dixon
  • Ronald L. Hayes
  • Stefania Mondello

Part of the Methods in Molecular Biology book series (MIMB, volume 1462)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Introduction

  3. General Consideration in Using Animal Laboratory in CNS Injury Research

    1. Front Matter
      Pages 9-9
    2. Justin Berkner, Rebekah Mannix, Jianhua Qiu
      Pages 11-28
    3. Elham Rostami
      Pages 47-59
    4. Ying Deng-Bryant, Ryan Readnower, Lai Yee Leung, Frank Tortella, Deborah Shear
      Pages 89-100
    5. Pamela J. VandeVord, Alessandra Dal Cengio Leonardi, David Ritzel
      Pages 101-118
    6. Zachary S. Bailey, W. Brad Hubbard, Pamela J. VandeVord
      Pages 119-138
    7. Zaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou-Abbass, Firas Kobeissy
      Pages 139-155
    8. Zaynab Jaber, Patrick Aouad, Mohamad Al Medawar, Hisham Bahmad, Hussein Abou-Abbass, Hiba Ghandour et al.
      Pages 157-174
  4. Classical TBI Models and Their Link with Pathophysiological Features of CNS Injury—Models

    1. Front Matter
      Pages 175-175
    2. Brian T. Kalish, Michael J. Whalen
      Pages 193-209
    3. Rachel K. Rowe, Daniel R. Griffiths, Jonathan Lifshitz
      Pages 211-230
    4. Sarah C. Hellewell, Jenna M. Ziebell, Jonathan Lifshitz, M. Cristina Morganti-Kossmann
      Pages 253-266
    5. Johan Davidsson, Mårten Risling
      Pages 267-288
    6. D. Kacy Cullen, James P. Harris, Kevin D. Browne, John A. Wolf, John E. Duda, David F. Meaney et al.
      Pages 289-324
    7. Bridgette D. Semple, Jaclyn Carlson, Linda J. Noble-Haeusslein
      Pages 325-343
    8. Jennifer C. Munoz Pareja, Kristen Keeley, Ann-Christine Duhaime, Carter P. Dodge
      Pages 345-356
    9. Ali Alawieh, Wenxue Wang, Aarti Narang, Stephen Tomlinson
      Pages 357-372
    10. Changhong Ren, Christopher Sy, Jinhuan Gao, Yuchuan Ding, Xunming Ji
      Pages 373-390
  5. Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury

    1. Front Matter
      Pages 391-391
    2. Dennis W. Simon, Vincent M. Vagni, Patrick M. Kochanek, Robert S. B. Clark
      Pages 393-411
    3. Shoji Yokobori, Markus S. Spurlock, Stephanie W. Lee, Shyam Gajavelli, Ross M. Bullock
      Pages 413-431
    4. Thangavelu Soundara Rajan, Salvatore Cuzzocrea, Daniele Bruschetta, Angelo Quartarone
      Pages 433-443
    5. Lai Yee Leung, Ying Deng-Bryant, Deborah Shear, Frank Tortella
      Pages 445-458
    6. Alexander V. Glushakov, Olena Y. Glushakova, Sylvain Doré, Paul R. Carney, Ronald L. Hayes
      Pages 481-519
    7. Floyd J. Thompson, Jiamei Hou, Prodip K. Bose
      Pages 521-536
  6. Outcome Measures in Brain Injury Models

    1. Front Matter
      Pages 537-537
    2. Ying Deng-Bryant, Lai Yee Leung, Krista Caudle, Frank Tortella, Deborah Shear
      Pages 539-551
    3. Jignesh D. Pandya, Patrick G. Sullivan, Lai Yee Leung, Frank C. Tortella, Deborah A. Shear, Ying Deng-Bryant
      Pages 597-610
    4. Crystal M. Ghantous, Zeina Azrak, Farah Abdel Rahman, Hana A. Itani, Asad Zeidan
      Pages 625-643
    5. Qiang Shen, Lora Tally Watts, Wei Li, Timothy Q. Duong
      Pages 645-658
    6. Hussein Gazalah, Sarah Mantash, Naify Ramadan, Sawsan Al Lafi, Sally El Sitt, Hala Darwish et al.
      Pages 689-710
  7. Future Directions in Neurotrauma Research

  8. Back Matter
    Pages 741-743

About this book


This volume discusses experimental brain injury models that contain valuable information carefully chosen to widen the researchers’ horizon about neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have been adapted and made ready for application in laboratory settings. For easier navigation, the chapters are categorized into 6 parts: Introduction, General Consideration in Using Animal Laboratory in CNS Injury Research, Classical TBI Models and Their Link with Pathophysiological Features of CBS Injury – Models, Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, Outcome Measures in Brain Injury Models, and Future Directions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols is a very useful reference towards the progress of this discipline.


traumatic brain injury (TBI) pediatric rodent models of TBI diffuse axonal injuries hypoxia hypoxemia epilepsy stem cell therapy small molecule inhibitors proteomics pressure myography mitochondrial bioenergetics

Editors and affiliations

  • Firas H. Kobeissy
    • 1
  • C. Edward Dixon
    • 2
  • Ronald L. Hayes
    • 3
  • Stefania Mondello
    • 4
  1. 1.Banyan Biomarkers, Inc.AlachuaUSA
  2. 2.Safar Center for Resuscitation ResearchUniversity of Pittsburgh Safar Center for Resuscitation ResearchPittsburghUSA
  3. 3.Banyan Biomarkers, Inc. AlachuaUSA
  4. 4.Banyan Biomarkers, Inc.AlachuaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-3814-8
  • Online ISBN 978-1-4939-3816-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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