Mouse Models for Drug Discovery

Methods and Protocols

  • Gabriele Proetzel
  • Michael V. Wiles

Part of the Methods in Molecular Biology book series (MIMB, volume 1438)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Benjamin E. Low, Peter M. Kutny, Michael V. Wiles
    Pages 19-53
  3. Benjamin E. Low, Rob A. Taft, Michael V. Wiles
    Pages 55-66
  4. Suheyla Hasgur, Ken Edwin Aryee, Leonard D. Shultz, Dale L. Greiner, Michael A. Brehm
    Pages 67-78
  5. Markus von Schaewen, Gabriela Hrebikova, Alexander Ploss
    Pages 79-101
  6. Derry C. Roopenian, Gregory J. Christianson, Gabriele Proetzel, Thomas J. Sproule
    Pages 103-114
  7. Yogesh Bhattarai, Purna C. Kashyap
    Pages 123-135
  8. Philip N. Howles
    Pages 177-197
  9. John P. Sundberg, Kathleen A. Silva, Lloyd E. King Jr, C. Herbert Pratt
    Pages 199-224
  10. Ashley J. Snider, Agnieszka B. Bialkowska, Amr M. Ghaleb, Vincent W. Yang, Lina M. Obeid, Yusuf A. Hannun
    Pages 245-254
  11. Carisa L. Bergner, Amanda N. Smolinsky, Peter C. Hart, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte et al.
    Pages 255-269
  12. Peter C. Hart, Carisa L. Bergner, Amanda N. Smolinsky, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte et al.
    Pages 271-291
  13. Christopher Janus, Carolina Hernandez, Victoria deLelys, Hanno Roder, Hans Welzl
    Pages 311-347
  14. Robert W. Burgess, Gregory A. Cox, Kevin L. Seburn
    Pages 349-394
  15. Mark P. Krebs, Mei Xiao, Keith Sheppard, Wanda Hicks, Patsy M. Nishina
    Pages 395-415
  16. Back Matter
    Pages 431-436

About this book


With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Practical and fully updated, Mouse Models for Drug Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview of techniques to utilize the many possibilities of mice in the drug development process.


Drug development Animal models Genetic engineering Humanized mice Pharmaceutical design

Editors and affiliations

  • Gabriele Proetzel
    • 1
  • Michael V. Wiles
    • 2
  1. 1.Takeda Pharmaceutical CompanyCambridgeUSA
  2. 2.The Jackson LaboratoryBar HarborUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-3659-5
  • Online ISBN 978-1-4939-3661-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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