Bacterial Therapy of Cancer

Methods and Protocols

  • Robert M Hoffman

Part of the Methods in Molecular Biology book series (MIMB, volume 1409)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Emily L. Brackett, Charles A. Swofford, Neil S. Forbes
    Pages 35-48
  3. Shun’ichiro Taniguchi, Yuko Shimatani, Minoru Fujimori
    Pages 49-60
  4. Michelle Cronin, Ali R. Akin, Kevin P. Francis, Mark Tangney
    Pages 69-77
  5. Chung-Jen Chiang, Chih-Hsiang Chang, Yun-Peng Chao, Ming-Ching Kao
    Pages 85-93
  6. K. Brooks Low, Sean R. Murray, John Pawelek, David Bermudes
    Pages 95-123
  7. Robert M. Hoffman, Ming Zhao
    Pages 143-164
  8. Robert M. Hoffman, Shuya Yano
    Pages 165-175
  9. Robert M. Hoffman
    Pages 177-184
  10. Back Matter
    Pages 185-186

About this book


This volume explores the evolution of bacterial cancer therapy and describes the modern techniques used in therapy today. The chapters in this book cover a broad range of topics such as the development of tumor-targeting Salmonella typhimurium A1-R, a microfluidic device for precise quantification of the interactions between tumor-targeting bacteria and tumor tissue, non-invasive in vivo imaging of bacteria-mediated cancer therapy using bio-luminescent bacteria, methods to achieve remote-control of therapeutic gene expression in tumor-targeting bacteria, and cell-cycle decoy of cancer cells resistant to cytotoxic drugs to drug sensitivity by S. typhimurium A1-R. This book concludes with a chapter on the future potential of bacterial therapy of cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Thorough and informative, Bacterial Therapy of Cancer: Methods and Protocols is a valuable resource for anyone who is interested in cancer and bacterial therapy.


bacterial cancer therapy tumor-targeting Salmonella mouse tumor model tumor tissue drug delivery system bio-luminescent bacteria therapeutic expression

Editors and affiliations

  • Robert M Hoffman
    • 1
  1. 1.Department of Surgery, AntiCancer IncUniv of California – San DiegoSan DiegoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-3513-0
  • Online ISBN 978-1-4939-3515-4
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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