Ion Channels and Transporters of Epithelia in Health and Disease

  • Kirk L. Hamilton
  • Daniel C Devor

Part of the Physiology in Health and Disease book series (PIHD)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Basic Epithelial Ion Transport Principles and Function

    1. Front Matter
      Pages 1-1
    2. Bruce D. Schultz, Daniel C. Devor
      Pages 3-47
    3. Alexander Staruschenko, Daria V. Ilatovskaya, Kenneth R. Hallows
      Pages 49-94
    4. Erik Hviid Larsen, Else Kay Hoffmann
      Pages 131-185
    5. Ivana Novak, Jeppe Praetorius
      Pages 187-263
    6. David P. Nickerson, Kirk L. Hamilton, Peter J. Hunter
      Pages 265-278
    7. Liang Zhang, Patrick H. Thibodeau
      Pages 303-331
  3. Epithelial Ion Channels and Transporters

    1. Front Matter
      Pages 333-333
    2. Jens Leipziger
      Pages 335-350
    3. Marcelino Cereijido, Isabel Larre, Omar Paez, Liora Shoshani, Arturo Ponce
      Pages 351-374
    4. Eric Delpire, Kenneth B. Gagnon
      Pages 375-400
    5. Arohan R. Subramanya
      Pages 401-435
    6. Aleksandra Sinđić, Michael F. Romero
      Pages 437-463
    7. Nikolay Shcheynikov, Ehud Ohana, Shmuel Muallem
      Pages 465-489
    8. John Cuppoletti, Danuta H. Malinowska, Ryuji Ueno
      Pages 491-518
    9. William T. Harris, Kevin L. Kirk
      Pages 519-552
    10. Paolo Scudieri, Luis J. V. Galietta
      Pages 553-567

About this book


This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. 
The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.


Epithelial ion transport Transepithelial secretion Potassium channels Sodium channels and absorption Chloride channels and transport Bicarbonate secretion Membrane protein folding and structure Kidney transport processes Maintaining homeostasis Cystic fibrosis

Editors and affiliations

  • Kirk L. Hamilton
    • 1
  • Daniel C Devor
    • 2
  1. 1.Department of PhysiologyUniversity of Otago DunedinNew Zealand
  2. 2.Department of Cell BiologyUniversity of PittsburghPittsburghUSA

Bibliographic information

  • DOI
  • Copyright Information American Physiological Society 2016
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4939-3364-8
  • Online ISBN 978-1-4939-3366-2
  • About this book
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