© 2016

Circulating Tumor Cells

  • Richard J. Cote
  • Ram H. Datar

Part of the Current Cancer Research book series (CUCR)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Technologies for CTC Identification

    1. Front Matter
      Pages 1-1
    2. Ram H. Datar, Zheng Ao, Richard J. Cote
      Pages 3-15
    3. Zheng Ao, Richard J. Cote, Ram H. Datar
      Pages 17-28
    4. Evi S. Lianidou, Athina Markou, Areti Strati
      Pages 47-74
    5. Ebrahim Azizi, Sunitha Nagrath, Molly Kozminsky, Max S. Wicha
      Pages 75-97
  3. Fundamental Studies of CTC

    1. Front Matter
      Pages 99-99
    2. Alison L. Allan, Ann F. Chambers
      Pages 101-120
    3. Bee Luan Khoo, Prashant Kumar, Chwee Teck Lim, Jean Paul Thiery
      Pages 139-182
  4. CTC Analysis

    1. Front Matter
      Pages 183-183
    2. Verena Tiran, Marija Balic, Nadia Dandachi
      Pages 185-199
    3. Mark Jesus M. Magbanua, John W. Park
      Pages 201-213
    4. Anthony Williams, Ramdane Harouaka, Siyang Zheng, Chris Albanese, Richard Schlegel, Yu-Chong Tai et al.
      Pages 215-231
    5. Jeffrey B. Smerage
      Pages 233-254
  5. Potential Clinical Applications of CTC

    1. Front Matter
      Pages 255-255
    2. Shih-Min A. Huang, Mark R. Lackner
      Pages 293-313

About this book


This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers.

CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive “liquid biopsy” procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development.There has been rapid progress in the field, fueled by research in basic science, biomedical engineering, and clinical applications. This book presents the latest developments from world-wide leaders, and will be useful for anyone interested in this important and expanding field.


biomarker cancer ctc metastasis tumor

Editors and affiliations

  • Richard J. Cote
    • 1
  • Ram H. Datar
    • 2
  1. 1.Jackson Memorial HospitalUniversity of MiamiMiamiUSA
  2. 2.University of MiamiMiamiUSA

About the editors

Richard J. Cote, M.D., is Chair, Department of Pathology, the University of Miami
Miller School of Medicine and the University of Miami Health System, and
Chief of Pathology, Jackson Memorial Hospital. As well, he is Director, the University of Miami Biomedical Nanoscience Institute. Dr. Cote, the recipient of more than $35 million in peer reviewed grant support, holds numerous patents for cancer-related and nanoscale technologies. Dr. Cote also serves as a member and advisor to numerous national and international study groups, cancer programs, and societies—including the National Cancer Institute. The editor and co-author of standard handbooks, Dr. Cote has published more than 300 scientific papers/documents, which have received 10,000 citations.

Ram Datar, Ph. D., is Co-Director, Biomedical Nanotechnology Institute, the University of Miami, Associate Professor, Pathology, Associate Professor, Biochemistry and Molecular Biology, the University of Miami Miller School of Medicine. Dr. Datar's areas of research focus include cancer
molecular pathology and biomedical nanotechnology. Specifically, he has
been involved in various aspects of detection and molecular characterization of occult metastases in cancers. For many years, he has also been involved in the development and application of micro- and nanoscale devices for biomedical diagnostic applications. His goal is to employ microfabrication and develo
pment of microfluidic devices to further novel technology
development, including biosensors and molecular methods to analyze expression profiles of cancers. Dr. Datar's many publications have received more than 2,200 citations.

Bibliographic information

  • Book Title Circulating Tumor Cells
  • Editors Richard J. Cote
    Ram Datar
  • Series Title Current Cancer Research
  • Series Abbreviated Title Current Cancer Research
  • DOI
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-4939-3361-7
  • Softcover ISBN 978-1-4939-8031-4
  • eBook ISBN 978-1-4939-3363-1
  • Series ISSN 2199-2584
  • Series E-ISSN 2199-2592
  • Edition Number 1
  • Number of Pages XXIV, 333
  • Number of Illustrations 2 b/w illustrations, 29 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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“The book will prove to be a useful resource for graduate students and established researchers with an interest in this field. It can provide a definitive source for the much-needed but often neglected theoretical framework for hospitals and laboratories desirous of establishing a CTC assay, in addition to providing practical tips. It should be included in the collection of libraries that cater to oncology clinicians, laboratory personnel as well as basic researchers.” (Sudeep Gupta, The National Medical Journal of India, Vol. 30 (1), January-February, 2017)

“The book is divided into four chapters that beyond of methodological issues summarize comprehensive information on biological nature, genesis, molecular characteristics, alterations, behaviour and clinical utility of CTCs. … ‘Circulating tumour cells’ brings us comprehensive review of current state-of-art in methodological approaches, clinical application and future perspectives of CTCs research.” (Bozena Smolkova, Neoplasma, Vol. 63 (5), 2016)