Circulating Tumor Cells

  • Richard J. Cote
  • Ram H. Datar

Part of the Current Cancer Research book series (CUCR)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Technologies for CTC Identification

    1. Front Matter
      Pages 1-1
    2. Ram H. Datar, Zheng Ao, Richard J. Cote
      Pages 3-15
    3. Zheng Ao, Richard J. Cote, Ram H. Datar
      Pages 17-28
    4. Evi S. Lianidou, Athina Markou, Areti Strati
      Pages 47-74
    5. Ebrahim Azizi, Sunitha Nagrath, Molly Kozminsky, Max S. Wicha
      Pages 75-97
  3. Fundamental Studies of CTC

    1. Front Matter
      Pages 99-99
    2. Alison L. Allan, Ann F. Chambers
      Pages 101-120
    3. Bee Luan Khoo, Prashant Kumar, Chwee Teck Lim, Jean Paul Thiery
      Pages 139-182
  4. CTC Analysis

    1. Front Matter
      Pages 183-183
    2. Verena Tiran, Marija Balic, Nadia Dandachi
      Pages 185-199
    3. Mark Jesus M. Magbanua, John W. Park
      Pages 201-213
    4. Anthony Williams, Ramdane Harouaka, Siyang Zheng, Chris Albanese, Richard Schlegel, Yu-Chong Tai et al.
      Pages 215-231
    5. Jeffrey B. Smerage
      Pages 233-254
  5. Potential Clinical Applications of CTC

    1. Front Matter
      Pages 255-255
    2. Shih-Min A. Huang, Mark R. Lackner
      Pages 293-313
    3. Rajan P. Kulkarni, Stefanie S. Jeffrey
      Pages 315-323
  6. Back Matter
    Pages 325-333

About this book


This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers.

CTCs are cells that have detached from the primary tumor and circulate in the bloodstream. Such cells may become "seeds" for the growth of additional tumors. The field of analysis surrounding cancer metastasis has been steadily growing, and CTCs provide effective biomarkers that can be examined in peripheral blood through a minimally invasive “liquid biopsy” procedure. CTCs offer several exciting applications, not only as markers of disease progression but also as biomarkers of monitoring response to therapy and companion diagnostics for novel anticancer drug development.There has been rapid progress in the field, fueled by research in basic science, biomedical engineering, and clinical applications. This book presents the latest developments from world-wide leaders, and will be useful for anyone interested in this important and expanding field.


biomarker cancer ctc metastasis tumor

Editors and affiliations

  • Richard J. Cote
    • 1
  • Ram H. Datar
    • 2
  1. 1.Jackson Memorial HospitalUniversity of MiamiMiamiUSA
  2. 2.University of MiamiMiamiUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4939-3361-7
  • Online ISBN 978-1-4939-3363-1
  • Series Print ISSN 2199-2584
  • Series Online ISSN 2199-2592
  • Buy this book on publisher's site
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