© 2015

Computational Systems Toxicology

  • Julia Hoeng
  • Manuel C. Peitsch

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-x
  2. Edward Perkins, Natàlia Garcia-Reyero, Stephen Edwards, Clemens Wittwehr, Daniel Villeneuve, David Lyons et al.
    Pages 1-26
  3. Miranda D. Stobbe
    Pages 27-63
  4. Dragana Mitic Potkrajac, Branka Rakic, Gordana Apic, Robert B. Russell
    Pages 95-108
  5. Natalia Boukharov, Jennifer S. Park
    Pages 145-160
  6. Simona Iacobacci, Francesco Gregoretti, Gennaro Oliva, Roman Polishchuk, Vincenzo Belcastro
    Pages 161-180
  7. Yukiko Matsuoka, Kazuhiro Fujita, Samik Ghosh, Hiroaki Kitano
    Pages 181-208
  8. Alain Sewer, Florian Martin, Walter K. Schlage, Julia Hoeng, Manuel C. Peitsch
    Pages 223-256
  9. Bjoern Titz, Thomas Schneider, Ashraf Elamin, Florian Martin, Sophie Dijon, Nikolai V. Ivanov et al.
    Pages 257-284
  10. Paul Walker, Tim Smith, Kerry Frost, Sarah Kelly, Ignacio Gonzalez Suarez
    Pages 317-344
  11. Simona Constantinescu, Shana J. Sturla, Giancarlo Marra, Bernd Wollscheid, Niko Beerenwinkel
    Pages 371-392
  12. Markus Nordlund, Arkadiusz K. Kuczaj
    Pages 393-427
  13. Back Matter
    Pages 429-430

About this book


This detailed volume explores key state-of-the-art computational applications that are crucial in Systems Toxicology.  The recent technological developments in experimental biology and multi-omics measurements that enable Systems Biology and Systems Toxicology can only be fully leveraged by the application of a broad range of computational approaches ranging from data management to mathematical modeling. Taking this into account, chapters in this book cover data management and processing, data analysis, biological network building and analysis, as well as the application of computational methods to toxicological assessment.

Written for the Methods in Pharmacology and Toxicology series, Computational Systems Toxicology includes the kind of key practical advice that will aid readers in furthering our knowledge of toxic substances and reactions to them.


Biological network models Computational approaches Data analysis Novel biomarkers Risk assessment Safety assessments and monitoring Toxic effects Toxicity testing Xenobiotic substances

Editors and affiliations

  • Julia Hoeng
    • 1
  • Manuel C. Peitsch
    • 2
  1. 1.Philip Morris International R&DNeuchâtelSwitzerland
  2. 2.Philip Morris International R&DNeuchâtelSwitzerland

Bibliographic information

  • Book Title Computational Systems Toxicology
  • Editors Julia Hoeng
    Manuel C. Peitsch
  • Series Title Methods in Pharmacology and Toxicology
  • Series Abbreviated Title Meth.Pharmacology,Toxicology
  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-1-4939-2777-7
  • Softcover ISBN 978-1-4939-5003-4
  • eBook ISBN 978-1-4939-2778-4
  • Series ISSN 1557-2153
  • Series E-ISSN 1940-6053
  • Edition Number 1
  • Number of Pages X, 430
  • Number of Illustrations 13 b/w illustrations, 96 illustrations in colour
  • Topics Pharmacology/Toxicology
    Systems Biology
  • Buy this book on publisher's site
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