Systems Biology of Alzheimer's Disease

  • Juan I. Castrillo
  • Stephen G. Oliver

Part of the Methods in Molecular Biology book series (MIMB, volume 1303)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Systems Biology of Multifactorial Diseases: Alzheimer’s Disease

    1. Front Matter
      Pages 1-1
    2. Simone Lista, Zaven S. Khachaturian, Dan Rujescu, Francesco Garaci, Bruno Dubois, Harald Hampel
      Pages 49-67
  3. Alzheimer’s Disease: Main Underlying Pathways and Networks

    1. Front Matter
      Pages 69-69
    2. Dorothea Pinotsi, Gabriele S. Kaminski Schierle, Clemens F. Kaminski
      Pages 125-141
    3. Alberto Rábano, Raquel Cuadros, Paula Merino-Serráis, Izaskun Rodal, Ruth Benavides-Piccione, Elena Gómez et al.
      Pages 143-160
    4. Anne Streeter, Fiona M. Menzies, David C. Rubinsztein
      Pages 161-170
    5. Diego Gomez-Nicola, V. Hugh Perry
      Pages 185-193
  4. Comprehensive Disease Models Recapitulating Alzheimer’s Disease Features: From Cellular Models to Human

    1. Front Matter
      Pages 195-195
    2. Mathias Verduyckt, Hélène Vignaud, Tine Bynens, Jeff Van den Brande, Vanessa Franssens, Christophe Cullin et al.
      Pages 197-215
    3. Jung Yeon Lim, Stanislav Ott, Damian C. Crowther
      Pages 227-239
    4. Nathalie G. Saurat, Frederick J. Livesey, Steven Moore
      Pages 267-278
  5. Experimental Systems Biology: Next Generation Molecular and High-Throughput Methods for the Study of Disease Susceptibility and Networks Dynamics Interplay in Complex Diseases

    1. Front Matter
      Pages 279-279
    2. Sheng Chih Jin, Bruno A. Benitez, Yuetiva Deming, Carlos Cruchaga
      Pages 299-314
    3. Bei Jun Chen, James D. Mills, Caroline Janitz, Michael Janitz
      Pages 327-347
    4. Dominic J. Hare, Alan Rembach, Blaine R. Roberts
      Pages 379-389
    5. Soichi Ogishima, Satoshi Mizuno, Masataka Kikuchi, Akinori Miyashita, Ryozo Kuwano, Hiroshi Tanaka et al.
      Pages 423-432
  6. Computational Systems Biology, Network Biology: Next Generation Computational and Integrative Network Biology Approaches for the Study of Modules, Network Dynamics, and Their Interplay in Complex Diseases

    1. Front Matter
      Pages 433-433
    2. Bin Zhang, Linh Tran, Valur Emilsson, Jun Zhu
      Pages 459-477
    3. Masataka Kikuchi, Soichi Ogishima, Satoshi Mizuno, Akinori Miyashita, Ryozo Kuwano, Jun Nakaya et al.
      Pages 479-491
  7. Systems Biology of Alzheimer’s Disease in Practice: From Systems Biology to Early Diagnostics and Systems Medicine

    1. Front Matter
      Pages 507-507
    2. Hongkang Mei, Gang Feng, Jason Zhu, Simon Lin, Yang Qiu, Yue Wang et al.
      Pages 531-547
  8. Back Matter
    Pages 549-563

About this book


Alzheimer’s disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic, and environmental factors. A proper investigation requires new integrative Systems Biology approaches, at both the experimental and computational level. The interplay of disease mechanisms and homeostatic networks will underlie the time of onset and rate of progression of the disease.


This book addresses such an integrated approach to AD. It aims to present Systems Biology, including both experimental and computational approaches, as a new strategy for the study of AD and other multifactorial diseases, with the hope that the results will translate into more effective diagnosis and treatment, as well as improved public health policies.


Written for the highly successful Methods in Molecular Biology series, practical and cutting-edge, Systems Biology of Alzheimer’s Disease is intended for post-graduate students, post-doctoral researchers, and experts in different fields with an interest in comprehensive Systems Biology strategies applicable to AD and other complex multifactorial diseases (including other neurodegenerative diseases and cancers). This book aims to complement other excellent volumes and monographs on AD that cover fundamental, physiological, or medical aspects of the disease.


Alzheimer’s disease (AD) Computational systems biology Disease models Disease risk classification Experimental systems biology Impaired and homeostatic networks Interactomes Network biology Next generation post-genomic techniques Omics Personalized medicine Proteostasis Stratification

Editors and affiliations

  • Juan I. Castrillo
    • 1
  • Stephen G. Oliver
    • 2
  1. 1.Department of Biochemistry & Cambridge Systems Biology CentreUniversity of CambridgeCambridgeUnited Kingdom
  2. 2.Department of Biochemistry & Cambridge Systems Biology CentreUniversity of CambridgeCambridgeUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2016
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-2626-8
  • Online ISBN 978-1-4939-2627-5
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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