© 2015

Cell Signaling During Mammalian Early Embryo Development

  • Henry J. Leese
  • Daniel R. Brison


  • Edited by two leaders in the field of reproductive biology

  • One of the first books on cell signaling in early embryo development

  • Covers signaling events from the zygote embryo through to the blastocyst


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 843)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Judith J. Eckert, Miguel A. Velazquez, Tom P. Fleming
    Pages 1-21
  3. Elizabeth E. Puscheck, Awoniyi O. Awonuga, Yu Yang, Zhongliang Jiang, Daniel A. Rappolee
    Pages 77-128
  4. C. O’Neill, Y. Li, X.L. Jin
    Pages 129-149
  5. Sarah A. Robertson, Peck-Yin Chin, John E. Schjenken, Jeremy G. Thompson
    Pages 173-213
  6. Back Matter
    Pages 215-216

About this book


The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.


assisted reproductive technology blastocyst cell signaling embryo-maternal dialogue preimplantation embryo

Editors and affiliations

  • Henry J. Leese
    • 1
  • Daniel R. Brison
    • 2
  1. 1.Hertford BuildingHull York Medical School University of HullHullUnited Kingdom
  2. 2.St. Mary's Hospital Department of Reproductive MedicineCentral Manchester University Hospitals NHS Foundation TrustManchesterUnited Kingdom

About the editors

Henry Leese, PhD, is a Professor of Biology at Hull York Medical School and the founding Editor-in-Chief of Human Fertility. Daniel  Brison, PhD, is Honorary Professor of Clinical Embryology and Stem Cell Biology; Scientific Director of the Department of Reproductive Medicine; and Co-Director NW Embryonic Stem Cell Centre (NWESCC) at Central Manchester University Hospitals NHS Foundation Trust at St. Mary’s Hospital.

Bibliographic information

  • Book Title Cell Signaling During Mammalian Early Embryo Development
  • Editors Henry J. Leese
    Daniel R. Brison
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Advs Exp. Medicine, Biology
  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4939-2479-0
  • Softcover ISBN 978-1-4939-4828-4
  • eBook ISBN 978-1-4939-2480-6
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XII, 216
  • Number of Illustrations 5 b/w illustrations, 16 illustrations in colour
  • Topics Embryology
    Cell Biology
    Reproductive Medicine
  • Buy this book on publisher's site