© 2015

Longevity Genes

A Blueprint for Aging

  • Gil Atzmon, PhD


  • Discusses innovative ways to use whole genome sequencing tools in the study of aging

  • Introduces readers to bio-statistical approaches to deal with the complex data set generated by whole genome sequencing when studying aging

  • Covers the whole palette of genetic component studies in order to expose readers to the major research efforts associated with aging today


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 847)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Diddahally R. Govindaraju
    Pages 1-44
  3. Yair Argon, Tali Gidalevitz
    Pages 45-72
  4. Nuria Martinez-Lopez, Diana Athonvarangkul, Rajat Singh
    Pages 73-87
  5. Linda Broer, Cornelia M. van Duijn
    Pages 107-125
  6. Erik B. van den Akker, Joris Deelen, P. Eline Slagboom, Marian Beekman
    Pages 127-139
  7. David Karasik, Anne Newman
    Pages 141-161
  8. Kendra Bolt, Aviv Bergman
    Pages 163-178
  9. Dan Ben-Avraham
    Pages 179-191
  10. Back Matter
    Pages 193-194

About this book


The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.


aging complex traits genes genomics phenotype

Editors and affiliations

  • Gil Atzmon, PhD
    • 1
  1. 1.Albert Einstein College of MedicineBronxUSA

Bibliographic information

  • Book Title Longevity Genes
  • Book Subtitle A Blueprint for Aging
  • Editors Gil Atzmon, PhD
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Advs Exp. Medicine, Biology
  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4939-2403-5
  • Softcover ISBN 978-1-4939-5555-8
  • eBook ISBN 978-1-4939-2404-2
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XI, 194
  • Number of Illustrations 2 b/w illustrations, 16 illustrations in colour
  • Topics Human Genetics
    Systems Biology
  • Buy this book on publisher's site
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