A Systems Biology Approach to Blood

  • Seth Joel Corey
  • Marek Kimmel
  • Joshua N. Leonard

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 844)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Basic Components

    1. Front Matter
      Pages 1-2
    2. Seth Joel Corey, Marek Kimmel, Joshua N. Leonard
      Pages 3-10
    3. Axel Krinner, Ingo Roeder
      Pages 11-36
    4. Miroslav Koulnis, Ermelinda Porpiglia, Daniel Hidalgo, Merav Socolovsky
      Pages 37-58
    5. Alexis Kaushansky, Kenneth Kaushansky
      Pages 59-84
    6. Yolande Chen, Seth Joel Corey, Oleg V. Kim, Mark S. Alber
      Pages 85-98
    7. Hrishikesh M. Mehta, Taly Glaubach, Seth Joel Corey
      Pages 99-113
  3. Physiological Processes

    1. Front Matter
      Pages 115-117
    2. Rosemary Braun
      Pages 153-187
    3. Julia Chifman, Reinhard Laubenbacher, Suzy V. Torti
      Pages 201-225
    4. Lily A. Chylek, Bridget S. Wilson, William S. Hlavacek
      Pages 245-262
    5. Elizabeth E. Gardiner, Robert K. Andrews
      Pages 263-275
  4. Clinical Applications

    1. Front Matter
      Pages 277-277
    2. Jinzhi Lei, Michael C. Mackey
      Pages 279-302
    3. Cristian Tomasetti
      Pages 303-316
    4. Tomas Radivoyevitch, Huamin Li, Rainer K. Sachs
      Pages 317-346
    5. Thomas Stiehl, Anthony D. Ho, Anna Marciniak-Czochra
      Pages 347-367
    6. Rachel M. Dudek, Yishan Chuang, Joshua N. Leonard
      Pages 369-391
  5. Epilogue

    1. Front Matter
      Pages 393-393
    2. Pankaj Qasba
      Pages 395-399
  6. Back Matter
    Pages 401-403

About this book


The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels.

A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.


hematopoiesis iron metabolism signaling systems stem cell systems biology systems hematology

Editors and affiliations

  • Seth Joel Corey
    • 1
  • Marek Kimmel
    • 2
  • Joshua N. Leonard
    • 3
  1. 1.Departments of Pediatrics and Cell & Molecular BiologyNorthwestern University Feinberg School of Medicine and Lurie Children’s Hospital of ChicagoChicagoUSA
  2. 2.Department of StatisticsRice UniversityHoustonUSA
  3. 3.Northwestern University Comprehensive Cancer CenterEvanstonUSA

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