Neurobiological Studies of Addiction in Chronic Pain States

  • Carolyn A. Fairbanks
  • Thomas J. Martin, Ph.D.

Part of the Contemporary Clinical Neuroscience book series (CCNE, volume 17)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

  3. Basic Science

    1. Front Matter
      Pages 15-15
    2. Wiebke Gandhi, Susanne Becker, Petra Schweinhardt
      Pages 31-48
    3. Minoru Narita, Keiichi Niikura, Akira Yamashita, Daigo Ikegami, Naoko Kuzumaki, Michiko Narita et al.
      Pages 49-58
  4. Methods

    1. Front Matter
      Pages 59-59
    2. Carrie L. Wade, George F. Koob, Leandro F. Vendruscolo
      Pages 61-79
  5. Clinical Perspectives

    1. Front Matter
      Pages 109-109
    2. Lisa M. Schrott
      Pages 111-117
    3. Scott A. Strassels
      Pages 119-127
  6. Back Matter
    Pages 129-132

About this book


Using rodent models, the contributors explore the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction. Combining various pain models with opioid self-administration and central administration pharmacotherapies allows researchers to answer important questions about:

1. The efficacy of opioid treatment under conditions of chronic pain of different etiology.

2. Alterations in the efficacy of opioid treatment under conditions of long-term opioid pharmacotherapy.

3. The potential for conversion or escalation of extra-analgesic motivation for opioid use beyond that required for pain relief.

4. The possibility of addiction development in chronic pain sufferers.

Merging the field of pain researchers with that of addiction research has presented some unique challenges and this volume seeks to provide some guidance for future study design in addition to a summary of current findings in the area.

Editors and affiliations

  • Carolyn A. Fairbanks
    • 1
  • Thomas J. Martin, Ph.D.
    • 2
  1. 1.Departments of Pharmaceutics, Pharmacology, NeuroscienceUniversity of MinnesotaMinneapolisUSA
  2. 2.Pain Mechanisms Laboratory, Department of AnesthesiologyWake Forest University Health SciencesWinston-SalemUSA

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