Amorphous Solid Dispersions

Theory and Practice

  • Navnit Shah
  • Harpreet Sandhu
  • Duk Soon Choi
  • Hitesh Chokshi
  • A. Waseem Malick

Part of the Advances in Delivery Science and Technology book series (ADST)

Table of contents

  1. Front Matter
    Pages i-xxii
  2. ASD Introduction

    1. Front Matter
      Pages 1-1
    2. Riikka Laitinen, Petra A. Priemel, Sachin Surwase, Kirsten Graeser, Clare J. Strachan, Holger Grohganz et al.
      Pages 35-90
    3. Harpreet Sandhu, Navnit Shah, Hitesh Chokshi, A.Waseem Malick
      Pages 91-122
    4. Siva Ram Kiran Vaka, Murali Mohan Bommana, Dipen Desai, Jelena Djordjevic, Wantanee Phuapradit, Navnit Shah
      Pages 123-161
  3. Technologies

    1. Front Matter
      Pages 163-163
    2. Qingyan Hu, Nicole Wyttenbach, Koji Shiraki, Duk Soon Choi
      Pages 165-195
    3. Chad Brown, James DiNunzio, Michael Eglesia, Seth Forster, Matthew Lamm, Michael Lowinger et al.
      Pages 197-230
    4. Chad Brown, James DiNunzio, Michael Eglesia, Seth Forster, Matthew Lamm, Michael Lowinger et al.
      Pages 231-260
    5. Filipe Gaspar, Joao Vicente, Filipe Neves, Jean-Rene Authelin
      Pages 261-302
    6. David T. Vodak, Michael Morgen
      Pages 303-322
    7. Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, Raman Iyer, A.Waseem Malick
      Pages 323-350
    8. Ralph Diodone, Hans J. Mair, Harpreet Sandhu, Navnit Shah
      Pages 351-371
    9. Raman Iyer, Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, A.Waseem Malick
      Pages 373-394
    10. Susanne Page, Reto Maurer
      Pages 395-417
  4. Characterization

    1. Front Matter
      Pages 419-419
    2. Amrit Paudel, Joke Meeus, Guy Van den Mooter
      Pages 421-485
    3. Nikoletta Fotaki, Chiau Ming Long, Kin Tang, Hitesh Chokshi
      Pages 487-514
    4. Xiang Kou, Liping Zhou
      Pages 515-544

About this book

Introduction

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems.

Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future. 

Keywords

amorphous dissolution mesoporous microprecipitation spray drying

Editors and affiliations

  • Navnit Shah
    • 1
  • Harpreet Sandhu
    • 2
  • Duk Soon Choi
    • 3
  • Hitesh Chokshi
    • 4
  • A. Waseem Malick
    • 5
  1. 1.Kashiv PharmaceuticalsBridgewaterUSA
  2. 2.Merck & Co., Inc.SummitUSA
  3. 3.Kashiv PharmaceuticalsBridgewaterUSA
  4. 4.Pharmaceutical Research & Early DevelopmentRoche Innovation CenterNew YorkUSA
  5. 5.Pharmaceutical and Analytical R&DHoffmann-La Roche Ltd.NutleyUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-1598-9
  • Copyright Information Controlled Release Society 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4939-1597-2
  • Online ISBN 978-1-4939-1598-9
  • Series Print ISSN 2192-6204
  • Series Online ISSN 2192-6212
  • About this book
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