© 2014

How Helminths Alter Immunity to Infection

  • William Horsnell
  • Reviews the current understanding of how helminth infections impact the ability to control unrelated infections

  • Covers new evidence about helminth infections controlling allergy and immune mechanisms

  • Examines helminth infections protecting against various auto-immune diseases


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 828)

Table of contents

  1. Front Matter
    Pages i-x
  2. Erin Logan, Alisha Chetty, William G. Horsnell
    Pages 1-26
  3. Kathrin Straubinger, Clarissa Prazeres da Costa
    Pages 27-48
  4. Nelita du Plessis, Gerhard Walzl
    Pages 49-74
  5. Saeeda Bobat, Adam F. Cunningham
    Pages 75-98
  6. Laura E. Layland, Sabine Specht
    Pages 99-129
  7. Back Matter
    Pages 151-152

About this book


Helminth infections are common, cause considerable pathology, and alter a host’s immune profile. This can have important consequences not only on the host’s ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question.

This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host’s anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child’s immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host’s ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies.


auto-immune disease helminth infections

Editors and affiliations

  • William Horsnell
    • 1
  1. 1.Division of Immunology/IIDMUniversity of Cape TownCape TownSouth Africa

About the editors

William Horsnell is an immunologist at the University of Cape Town, South Africa. His research interests center on how parasitic helminth infections alter host immunity and the ability to control both the helminth and unrelated diseases.

Bibliographic information

  • Book Title How Helminths Alter Immunity to Infection
  • Editors William Horsnell
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Advs Exp. Medicine, Biology
  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4939-1488-3
  • Softcover ISBN 978-1-4939-5419-3
  • eBook ISBN 978-1-4939-1489-0
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages X, 152
  • Number of Illustrations 0 b/w illustrations, 6 illustrations in colour
  • Topics Immunology
    Infectious Diseases
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals