Mass Spectrometry Imaging of Small Molecules

  • Lin He

Part of the Methods in Molecular Biology book series (MIMB, volume 1203)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Nicholas Winograd, Anna Bloom
    Pages 9-19
  3. David Touboul, Alain Brunelle
    Pages 21-27
  4. Andrew R. Korte, Gargey B. Yagnik, Adam D. Feenstra, Young Jin Lee
    Pages 49-62
  5. Elaine C. Cabral, Demian R. Ifa
    Pages 63-77
  6. Rachel V. Bennett, Facundo M. Fernández
    Pages 79-89
  7. Sung-Gun Park, Kermit K. Murray
    Pages 129-139
  8. Michael E. Kurczy, Trent R. Northen, Sunia A. Trauger, Gary Siuzdak
    Pages 141-149
  9. Tara N. Moening, Victoria L. Brown, Lin He
    Pages 151-157
  10. Michihiko Waki, Eiji Sugiyama, Takeshi Kondo, Keigo Sano, Mitsutoshi Setou
    Pages 159-173
  11. Artem Akhmetov, Chhavi Bhardwaj, Luke Hanley
    Pages 185-194
  12. Jiangjiang Liu, Xingchuang Xiong, Zheng Ouyang
    Pages 195-209
  13. Back Matter
    Pages 211-213

About this book


Mass Spectroscopy Imaging (MSI) has emerged as an enabling technique to provide insight into the molecular entities within cells, tissues and whole-body samples and to understand inherent complexities within biological metabolomes. In Mass Spectrometry Imaging of Small Molecules, experts in the MSI field present techniques for 2D and 3D visualization and quantification of a wide array of small molecular species present in biologically relevant samples. Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification, and from data collection to visualization of small molecule mapping in complex samples. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.


Authoritative and easily accessible, Mass Spectrometry Imaging of Small Molecules aims to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research.


MALDI-MS biological metabolomes mass spectrometry mass spectrometry imaging molecular imaging

Editors and affiliations

  • Lin He
    • 1
  1. 1.Department of ChemistryNorth Carolina State UniversityRaleighUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2015
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-1356-5
  • Online ISBN 978-1-4939-1357-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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