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Systems Biology of RNA Binding Proteins

  • Gene W. Yeo

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 825)

Table of contents

  1. Front Matter
    Pages i-x
  2. Stefanie Gerstberger, Markus Hafner, Manuel Ascano, Thomas Tuschl
    Pages 1-55
  3. Ling-Ling Chen, Jing Crystal Zhao
    Pages 129-158
  4. Josef P. Clark, Nelson C. Lau
    Pages 159-197
  5. Rachel Soemedi, Hugo Vega, Judson M. Belmont, Sohini Ramachandran, William G. Fairbrother
    Pages 227-266
  6. Marianne Goodwin, Maurice S. Swanson
    Pages 353-388
  7. Jimena Giudice, Thomas A. Cooper
    Pages 389-429
  8. Sarah Azoubel Lima, Amy E. Pasquinelli
    Pages 431-450
  9. Yoseph Barash, Jorge Vaquero-Garcia
    Pages 451-466
  10. Back Matter
    Pages 467-468

About this book

Introduction

After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs within target RNAs and which control the temporal, functional and spatial dynamics of the target RNA define a putative “mRNP code”. These cis-regulatory RNA elements can be found in the 5’ and 3’ untranslated regions (UTRs), introns, and exons of all protein-coding genes. RNA elements in 5’ and 3’ UTRs are frequently involved in targeting RNA to specific cellular compartments, affecting 3’ end formation, controlling RNA stability and regulating mRNA translation. RNA elements in introns and exons are known to function as splicing enhancers or silencers during the splicing process from pre-mRNA to mature mRNA.

This book provides case studies of RNA binding proteins that regulate aspects of RNA processing that are important for fundamental understanding of diseases and development. Chapters include systems-level perspectives, mechanistic insights into RNA processing and RNA Binding proteins in genetic variation, development and disease. The content focuses on systems biology and genomics of RNA Binding proteins and their relation to human diseases.

Keywords

Protein-RNA interactions RNA Binding Proteins RNA processing systems biology

Editors and affiliations

  • Gene W. Yeo
    • 1
  1. 1.UCSD Moores Cancer CenterInstitute for Genomic Medicine UCSD Stem Cell ProgramLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-1221-6
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4939-1220-9
  • Online ISBN 978-1-4939-1221-6
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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