Pharmacogenomics in Drug Discovery and Development

  • Qing Yan

Part of the Methods in Molecular Biology book series (MIMB, volume 1175)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Systems and “Omics” Studies in Pharmacogenomics

    1. Front Matter
      Pages 1-1
    2. Raffaele Palmirotta, Maria Laura De Marchis, Giorgia Ludovici, Patrizia Ferroni, Pasquale Abete, Fiorella Guadagni et al.
      Pages 45-65
    3. Tristan M. Sissung, Andrew K. L. Goey, Ariel M. Ley, Jonathan D. Strope, William D. Figg
      Pages 91-120
    4. Miles D. Thompson, David E. C. Cole, Pedro A. Jose, Peter Chidiac
      Pages 121-152
    5. Miles D. Thompson, Geoffrey N. Hendy, Maire E. Percy, Daniel G. Bichet, David E. C. Cole
      Pages 153-187
    6. Miles D. Thompson, David E. C. Cole, Valerie Capra, Katherine A. Siminovitch, G. Enrico Rovati, W. McIntyre Burnham et al.
      Pages 189-242
  3. Clinical Applications of Pharmacogenomics

    1. Front Matter
      Pages 243-243
    2. Anastasios Lymperopoulos, Faren French
      Pages 245-257
    3. Efi Valanti, Alexandros Tsompanidis, Despina Sanoudou
      Pages 259-300
    4. Ramón Cacabelos, Pablo Cacabelos, Clara Torrellas, Iván Tellado, Juan C. Carril
      Pages 323-556
    5. Jennie G. Pouget, Daniel J. Müller
      Pages 557-587
    6. David A. Nielsen, Ellen M. Nielsen, Teja Dasari, Catherine J. Spellicy
      Pages 589-624
    7. Deepali Sen, Jisna R. Paul, Prabha Ranganathan
      Pages 625-660
    8. José A. Riancho, Flor M. Pérez-Campo
      Pages 661-670
    9. Michael Rieder
      Pages 687-707
  4. Back Matter
    Pages 709-715

About this book


Covering topics from individual molecules to systemic diseases, from basic concepts to advanced technologies, Pharmacogenomics in Drug Discovery and Development , Second Edition provides a practical, state-of-the-art and integrative view of the application of pharmacogenomics in drug discovery and development. A wide range of theoretical and experimental approaches are introduced to meet the problem-solving objectives for understanding the complexity in health and diseases, from laboratory tests to computational analysis. The development of pharmacogenomics represents the evolution of biomedicine from treating the disease itself to treating the malfunction of an individual person, the “root” of diseases. With the change of focus from disease-centered to human-centric medicine, pharmacogenomics brings hope for the transformation from simple disease treatment to accurate prediction and effective prevention. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.


Authoritative and easily accessible, Pharmacogenomics in Drug Discovery and Development, Second Edition seeks to serve both professionals and novices with comprehensive resources and a holistic view for the translation of pharmacogenomics into better preventive and personalized medical care.


bioinformatics drug development dynamical medicine human genetic diseases pharmacogenomic studies pharmacogenomics

Editors and affiliations

  • Qing Yan
    • 1
  1. 1.PharmTaoSanta ClaraUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-0955-1
  • Online ISBN 978-1-4939-0956-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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