Central Functions of the Ghrelin Receptor

  • Jeanelle Portelli
  • Ilse Smolders

Part of the The Receptors book series (REC, volume 25)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. The ghrelin receptor isoforms

    1. Front Matter
      Pages 1-1
    2. Jacek Mokrosiński, Andreas Nygaard Madsen, Birgitte Holst
      Pages 3-19
    3. Alessandro Laviano, Alessia Mari
      Pages 21-31
  3. Mechanisms of Ghrelin’s Action

    1. Front Matter
      Pages 33-33
    2. Romana Stark, Zane B. Andrews
      Pages 35-52
    3. Yukari Date
      Pages 53-61
  4. Ghrelin Receptors in Food and Drug Addictive Mechanisms

    1. Front Matter
      Pages 63-63
    2. Mario Perello, Jesica Raingo
      Pages 65-88
    3. Harriët Schellekens, Timothy G. Dinan, John F. Cryan
      Pages 89-122
    4. Allison A. Feduccia, Lorenzo Leggio
      Pages 135-149
  5. Ghrelin Plays a Role in Various Physiological and Pathophysiological Brain Functions

    1. Front Matter
      Pages 151-151
    2. Éva Szentirmai, Levente Kapás
      Pages 153-165
    3. Nicolas Kunath, Martin Dresler
      Pages 167-175
    4. Jeanelle Portelli, Ann Massie, Jessica Coppens, Ilse Smolders
      Pages 177-189
    5. Marcus M. Unger, Wolfgang H. Oertel
      Pages 205-211
  6. Back Matter
    Pages 213-214

About this book


The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system.
In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson’s disease, epilepsy, anxiety and depression.


addicton constitutive receptor activity food intake ghrelin receptors pathophysiology

Editors and affiliations

  • Jeanelle Portelli
    • 1
  • Ilse Smolders
    • 2
  1. 1.Center for NeurosciencesVrije Universiteit BrusselBrusselsBelgium
  2. 2.Center for NeurosciencesVrije Universiteit BrusselBrusselsBelgium

Bibliographic information

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