Cancer Biology and the Nuclear Envelope

Recent Advances May Elucidate Past Paradoxes

  • Eric C. Schirmer
  • Jose I. de las Heras

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 773)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. History and Use of the Nuclear Envelope in Cancer Prognosis

    1. Front Matter
      Pages 1-4
    2. Jos L. V. Broers, Frans C. S. Ramaekers
      Pages 27-48
    3. Robert W. Veltri, Christhunesa S. Christudass
      Pages 77-99
    4. Gianni Bussolati, Francesca Maletta, Sofia Asioli, Laura Annaratone, Anna Sapino, Caterina Marchiò
      Pages 101-121
  3. The Nuclear Envelope in Cell Cycle Regulation and Signaling

    1. Front Matter
      Pages 123-125
    2. Brian K. Kennedy, Juniper K. Pennypacker
      Pages 127-142
    3. Michael I. Robson, Phu Le Thanh, Eric C. Schirmer
      Pages 165-185
    4. Jason C. Choi, Howard J. Worman
      Pages 187-206
  4. Nuclear Envelope Regulation of the Genome

    1. Front Matter
      Pages 207-208
    2. Roman Lyakhovetsky, Yosef Gruenbaum
      Pages 245-262
    3. Joanna M. Bridger, Halime D. Arican-Gotkas, Helen A. Foster, Lauren S. Godwin, Amanda Harvey, Ian R. Kill et al.
      Pages 263-279
  5. Functions of the NPC in Cancer

    1. Front Matter
      Pages 281-283
    2. Dan N. Simon, Michael P. Rout
      Pages 285-307
    3. Chelsi J. Snow, Bryce M. Paschal
      Pages 309-322
    4. Kyle B. Matchett, Suzanne McFarlane, Sophie E. Hamilton, Yousef S. A. Eltuhamy, Matthew A. Davidson, James T. Murray et al.
      Pages 323-351
    5. Manisha Sharma, Michael Johnson, Mariana Brocardo, Cara Jamieson, Beric R. Henderson
      Pages 353-372
  6. The Nuclear Envelope in DNA Damage and Stress Responses

  7. The Nuclear Envelope Link to Cell Migration and Metastasis

    1. Front Matter
      Pages 431-433
    2. Celine Denais, Jan Lammerding
      Pages 435-470
    3. David Razafsky, Denis Wirtz, Didier Hodzic
      Pages 471-490
    4. Sascha Neumann, Angelika A. Noegel
      Pages 491-504
  8. Towards a Molecular Explanation of Prognostic Links to the Nuclear Envelope

    1. Front Matter
      Pages 521-522
    2. Ashraf N. Malhas, David J. Vaux
      Pages 523-535
    3. Predrag Jevtić, Daniel L. Levy
      Pages 537-569
    4. Masatoshi Takagi, Naoko Imamoto
      Pages 571-591
    5. Christopher J. Hutchison
      Pages 593-604
  9. Joanna M. Bridger, Halime D. Arican-Gotkas, Helen A. Foster, Lauren S. Godwin, Amanda Harvey, Ian R. Kill et al.
    Pages E1-E1
  10. Back Matter
    Pages 605-611

About this book


"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE  is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology.
This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."


DNA cell cycle regulation nuclear envelope signalling stress response

Editors and affiliations

  • Eric C. Schirmer
    • 1
  • Jose I. de las Heras
    • 2
  1. 1.University of Edinburgh Wellcome Trust Centre for Cell BiologyEdinburghUnited Kingdom
  2. 2.University of Edinburgh Wellcome Trust Centre for Cell BiologyEdinburghUnited Kingdom

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