Cerebrospinal Fluid in Neurology and Psychiatry

  • H. McConnell
  • J. Bianchine

Table of contents

  1. Front Matter
    Pages i-xiv
  2. H. McConnell
    Pages 1-4
  3. H. McConnell, J. Bianchine, E. Wilder-Smith, A. Wilder-Smith, D. Rillstone
    Pages 5-33
  4. J. Bianchine, H. McConnell
    Pages 35-42
  5. H. McConnell, D. Rillstone
    Pages 43-56
  6. H. McConnell, J. Bianchine, A. Wilder-Smith
    Pages 57-109
  7. H. McConnell, E. Wilder-Smith, A. Wilder-Smith, J. Brillman, U. Roelcke, H. Nukada
    Pages 111-171
  8. H. McConnell
    Pages 173-216
  9. H. McConnell, T. Scott
    Pages 217-229
  10. Back Matter
    Pages 237-322

About this book


Scientists have speculated as to the nature of cerebrospinal fluid (CSF) - "the third circulation" or "vital spirit" for centuries. Just what is this mysterious bathing solution of the central nervous system? Is it a vehicle of transport for an "animal spirit" directing all our activities, as thought by Galen (Singer, 1956) or but a "modified tap water" (Halliburton, 1917)? With the advent of lumbar puncture, cerebrospinal fluid has become a readily available and important means of studying disease affecting the nervous system. In recent years, many sophisticated tools including com­ puter guided gas chromatography/mass spectrometry and high performance liquid chromatography have made it possible to identify and quantify many constituents of this fluid. The CSF has an enormous, though largely "untapped", potential in aiding diagnosis and evaluating treatment of many neurological, psychiatric and systemic disorders. As the ependyma is only a diffusional barrier between the CSF and extracellular fluid of the brain for many compounds, changes in the concentration of these compounds in the CSF may reflect disease processes in the brain.


Nervous System brain diagnosis neurology psychiatry

Editors and affiliations

  • H. McConnell
    • 1
    • 2
  • J. Bianchine
    • 3
  1. 1.Department of Physiology and Psychological MedicineUniversity of Otago Medical SchoolDunedinNew Zealand
  2. 2.Department of Neurology and PsychiatryAllegheny Neuropsychiatric Institute, Medical College of PennsylvaniaOakdaleUSA
  3. 3.Department of Pharmacology, College of Medicine and Adria LaboratoriesOhio State UniversityColumbusUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1994
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-412-53570-3
  • Online ISBN 978-1-4899-3372-0
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Consumer Packaged Goods