The Design of Synthetic Inhibitors of Thrombin

  • Goran Claeson
  • Michael F. Scully
  • Vijay V. Kakkar
  • John Deadman

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 340)

Table of contents

  1. Front Matter
    Pages i-x
  2. J. W. Fenton II, F. Ni, J. I. Witting, D. V. Brezniak, T. T. Andersen, A. B. Malik
    Pages 1-13
  3. David W. Banner, Paul Hadváry
    Pages 27-33
  4. Stuart R. Stone, Andreas Betz, Marina A. A. Parry, Martin P. Jackman, Jan Hofsteenge
    Pages 35-49
  5. Manfred Philipp, Ling-Hao Niua, Tushini DeSoyza, Göran Claeson, Rainer Metternich
    Pages 67-77
  6. G. Claeson, S. Elgendy, L. Cheng, N. Chino, C. A. Goodwin, M. F. Scully et al.
    Pages 83-89
  7. Charles Kettner, Robert M. Knabb
    Pages 109-118
  8. S. Okamoto, K. Wanaka, A. Hijikata-Okunomiya
    Pages 119-130
  9. M. F. Scully, J. Deadman, L. Cheng, C. A. Goodwin, V. Ellis, V. V. Kakkar et al.
    Pages 131-141
  10. Said Elgendy, John Deadman, Goran Claeson
    Pages 173-178
  11. L. Cheng, C. A. Goodwin, M. F. Scully, J. Deadman, G. Claeson
    Pages 179-184
  12. B. Neises, C. Tarnus, R. J. Broersma, C. Bald, J. M. Rémy, E. F. Heminger
    Pages 185-188
  13. W. Jetten, J. A. M. Peters, A. Visser, P. D. J. Grootenhuis, H. C. J. Ottenheijm
    Pages 189-190
  14. Fritz Markwardt
    Pages 191-211
  15. Back Matter
    Pages 243-246

About this book


In one generation, the numerous factors involved in blood coagulation have become real protein entities, isolated in pure form, expressed by recombinant DNA techniques, and subjected to structure elucidation by the modem methods of physical chemistry, viz. , X-ray diffraction, and NMR, ESR and fluorescence spectroscopy. The major milestone in this field was the breakthrough achieved by W. Bode, R. Huber and their colleagues in 1989 in of human a-thrombin, inhibited with D-Phe-Pro-Arg determining the crystal structure chioromethyl ketone. The availability of this structure will greatly facilitate the interpretation of experiments designed to gain an understanding of the interatomic interactions between this enzyme and fibrinogen and its other substrates. At the same time, it provides a rational basis for the design and synthesis of inhibitors of thrombin, the subject of this symposium. The symposium was organized in four sessions: (1) Structural features of the interaction of thrombin with substrates and inhibitors, (2) Synthetic inhibitors, (3) Hirudin and its analogues, and (4) Pharmacological and clinical considerations. This book contains summaries of most of the papers presented, and takes its rigbful place among two others that provide a comprehensive picture of our current knowledge about thrombin, viz. the 1977 volume entitled "Chemistry and Biology of Thrombin", edited by R. L. Lundblad, J. W. Fenton II, and K. G. Mann, and the 1992 volume entitled "Thrombin: Structure and Function", edited by L. J. Berliner.


DNA biology chemistry enzyme enzymes molecular modelling protein research synthesis

Editors and affiliations

  • Goran Claeson
    • 1
  • Michael F. Scully
    • 1
  • Vijay V. Kakkar
    • 1
  • John Deadman
    • 1
  1. 1.Thrombosis Research InstituteLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-2420-9
  • Online ISBN 978-1-4899-2418-6
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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