Insecticide Biochemistry and Physiology

  • C. F. Wilkinson

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Penetration and Distribution

    1. Front Matter
      Pages 1-1
    2. Gerald Thomas Brooks
      Pages 3-58
  3. Metabolism

    1. Front Matter
      Pages 59-59
    2. Tsutomu Nakatsugawa, Michael A. Morelli
      Pages 61-114
    3. Ernest Hodgson, Laurence G. Tate
      Pages 115-148
    4. W. C. Dauterman
      Pages 149-176
    5. Raymond S. H. Yang
      Pages 177-225
  4. Target Site Interactions

    1. Front Matter
      Pages 227-227
    2. R. D. O’Brien
      Pages 271-296
    3. Jun-ichi Fukami
      Pages 353-396
  5. Selectivity and Resistance

    1. Front Matter
      Pages 429-429
    2. F. J. Oppenoorth, W. Welling
      Pages 507-551
  6. Insecticide Toxicology

    1. Front Matter
      Pages 553-553
    2. C. F. Wilkinson
      Pages 605-647
    3. John Doull
      Pages 649-667
    4. Wendell W. Kilgore, Ming-yu Li
      Pages 669-713
  7. Back Matter
    Pages 715-768

About this book


Only four short decades ago, the control of insect pests by means of chemicals was in its early infancy. The pioneers in the area consisted largely of a group of dedicated applied entomologists working to the best of their abilities with a very limited arsenal of chemicals that included inorganics (arsenicals, fluorides, etc.), some botanicals (nicotine), and a few synthetic organics (dinitro-o-cresol, organothiocyanates). Much of the early research was devoted to solving practical problems associated with the formulation and application of the few existing materials, and although the discovery of new types of insecticidal chemicals was undoubtedly a pipe dream in the minds of some, little or no basic research effort was expended in this direction. The discovery of the insecticidal properties of DDT by Paul Miiller in 1939 has to be viewed as the event which marked the birth of modern insecticide chemistry and which has served as the cornerstone for its subse­ quent developement. DDT clearly demonstrated for the first time the dramatic potential of synthetic organic chemicals for insect control and provided the initial stimulus which has caused insecticide chemistry to become a field not only of immense agricultural and public health importance but also one that has had remarkable and unforseeable repercussions in broad areas of the physical, biological, and social sciences. Indeed, there can be few other synthetic chemicals which will be judged in history to have had such a broad and telling impact on mankind as has DDT.


Oxidation biochemistry chemistry cytochrome P450 environment insect metabolism nervous system pharmacology physiology receptor research resistance toxicity toxicology

Editors and affiliations

  • C. F. Wilkinson
    • 1
  1. 1.Cornell UniversityIthacaUSA

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