Electrochemical Sensors in Immunological Analysis

  • T. T. Ngo

Table of contents

  1. Front Matter
    Pages i-xi
  2. Michael Thompson, Joseph S. Tauskela, Ulrich J. Krull
    Pages 1-18
  3. Shuichi Suzuki, Masuo Aizawa
    Pages 47-59
  4. H. Allen O. Hill, Nicholas J. Walton
    Pages 61-75
  5. Sam A. McClintock, William C. Purdy
    Pages 77-85
  6. Matthew J. Doyle, Kenneth R. Wehmeyer, William R. Heineman, H. Brian Halsall
    Pages 87-102
  7. D. Scott Wright, H. Brian Halsall, William R. Heineman
    Pages 117-130
  8. Shia S. Kuan, George G. Guilbault
    Pages 145-165
  9. Isao Karube, Eiichi Tamiya
    Pages 293-307
  10. Kenneth R. Wehmeyer, Matthew J. Doyle, H. Brian Halsall, William R. Heineman
    Pages 309-325
  11. Back Matter
    Pages 351-360

About this book


The development of radioimmunoassay (RIA) by R.S. Yalow and S.A. Berson in 1959 opens up a new avenue in ultra­ sensitive analysis of trace substances in complex biological systems. In recognition of the enormous contributions of RIA to basic research in biology and to routine clinical tests in laboratory medicine, R.S. Yalow, the co-developer of RIA, was awarded, in 1977, the Nobel Prize for Medicine and Physiology. The basic principle of RIA is elegantly simple. It is based on a specific, competitive binding reaction between the analyte and the radio-labeled analog of the analyte for the specific antibody raised to the analyte. The combination of high specificity and affinity of an antibody molecule makes it a very versatile analytical reagent capable of reacting specifically with analytes at a very low concentration in a complex solution such as serum. The sensitivity of RIA is provided by using a radioactive tracer.


Antigen enzymes laboratory medicine physiology protein reaction

Editors and affiliations

  • T. T. Ngo
    • 1
  1. 1.University of California, IrvineIrvineUSA

Bibliographic information

Industry Sectors
Consumer Packaged Goods