Ubiquitin and the Biology of the Cell

  • Jan-Michael Peters
  • J. Robin Harris
  • Daniel Finley

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Avram Hershko
    Pages 1-17
  3. Cecile M. Pickart
    Pages 19-63
  4. Martin Scheffner, Susan Smith, Stefan Jentsch
    Pages 65-98
  5. Keith D. Wilkinson, Mark Hochstrasser
    Pages 99-125
  6. Andrei Lupas, Wolfgang Baumeister
    Pages 127-146
  7. Martin Rechsteiner
    Pages 147-189
  8. Jochen Beninga, Alfred L. Goldberg
    Pages 191-222
  9. A. Varshavsky, C. Byrd, I. V. Davydov, R. J. Dohmen, F. Du, M. Ghislain et al.
    Pages 223-278
  10. Mark Hochstrasser, Daniel Kornitzer
    Pages 279-302
  11. Zhijian J. Chen, Tom Maniatis
    Pages 303-322
  12. Jon M. Huibregtse, Carl G. Maki, Peter M. Howley
    Pages 323-343
  13. Jan-Michael Peters, Randall W. King, Raymond J. Deshaies
    Pages 345-387
  14. Philip Coffino
    Pages 411-428
  15. R. John Mayer, Michael Landon, James Lowe
    Pages 429-462
  16. Back Matter
    Pages 463-472

About this book


The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re­ counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.


biology cell biology membrane proteins protein transcription

Editors and affiliations

  • Jan-Michael Peters
    • 1
  • J. Robin Harris
    • 2
  • Daniel Finley
    • 3
  1. 1.Research Institute of Molecular PathologyViennaAustria
  2. 2.Institute of ZoologyUniversity of MainzMainzGermany
  3. 3.Harvard Medical SchoolBostonUSA

Bibliographic information

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