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Novel Strategies in the Design and Production of Vaccines

  • Book
  • © 1996

Overview

Editors:
  1. Sara Cohen

    1. Israel Institute for Biological Research, Ness-Ziona, Israel

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  2. Avigdor Shafferman

    1. Israel Institute for Biological Research, Ness-Ziona, Israel

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 397)

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Table of contents (23 chapters)

  1. Production Processes and Clinical Evaluation

    1. Analysis of Bordetella pertussis Suspensions by ELISA and Flow Cytometry

      • W. Jiskoot, J. Westdijk, C. H. K. Reubsaet, E. C. Beuvery
      Pages 153-157

    2. Clinical Trials of Shigella Vaccines in Israel

      • D. Cohen, S. Ashkenazi, M. Green, M. Gdalevich, M. Yavzori, N. Orr et al.
      Pages 159-167

  2. Vaccine Development - General Consideration

    1. Hypothesis: How Licensed Vaccines Confer Protective Immunity

      • John B. Robbins, Rachel Schneerson, Shousun C. Szu
      Pages 169-182

    2. Therapeutic Vaccines

      • R. E. Spier
      Pages 183-189

  3. Back Matter

    Pages 191-197
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Keywords

About this book

Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno­ genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep­ tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).

Editors and Affiliations

  • Israel Institute for Biological Research, Ness-Ziona, Israel

    Sara Cohen, Avigdor Shafferman

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