© 1996

Novel Strategies in the Design and Production of Vaccines

  • Sara Cohen
  • Avigdor Shafferman

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 397)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Recombinant Antigens and Presentation Vectors

    1. Bernard Moss, Miles W. Carroll, Linda S. Wyatt, Jack R. Bennink, Vanessa M. Hirsch, Simoy Goldstein et al.
      Pages 7-13
    2. F. Schödel, S. Kelly, S. Tinge, S. Hopkins, D. Peterson, D. Milich et al.
      Pages 15-21
    3. Charles M. Rice
      Pages 31-40
    4. A. Shafferman, S. Lustig, Y. Inbar, M. Halevy, P. Schneider, T. Bino et al.
      Pages 41-47
    5. J. B. Ulmer, R. R. Deck, A. Yawman, A. Friedman, C. Dewitt, D. Martinez et al.
      Pages 49-53
  3. Bacterial Vaccines - Novel Approaches

    1. Rino Rappuoli, Mariagrazia Pizza, Gill Douce, Gordon Dougan
      Pages 55-60
    2. C. Pezard, J.-C. Sirard, M. Mock
      Pages 69-72
    3. Jan T. Poolman
      Pages 73-77
  4. Strategies for HIV Vaccine

    1. Alan M. Schultz
      Pages 79-90
    2. J. M. Gershoni, G. F. Denisova, D. Raviv, B. Stern, J. Zwickel
      Pages 91-96
    3. Yechiel Becker
      Pages 97-104
  5. Adjuvants and Delivery Systems

    1. Rajesh K. Gupta, Paul Griffin Jr., An-Cheng Chang, Rachel Rivera, Roger Anderson, Bradford Rost et al.
      Pages 105-113
    2. D. Katz, S. Lehrer, O. Galan, B. Lachmi, S. Cohen, I. Inbar et al.
      Pages 115-125
  6. Production Processes and Clinical Evaluation

    1. O.-W. Merten, C. Hannoun, J.-C. Manuguerra, F. Ventre, S. Petres
      Pages 141-151

About this book


Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno­ genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep­ tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).


AIDS HIV antigen autoimmune disease bacteria bacterial infection bacterial infections infection infections infectious vaccine virus

Editors and affiliations

  • Sara Cohen
    • 1
  • Avigdor Shafferman
    • 1
  1. 1.Israel Institute for Biological ResearchNess-ZionaIsrael

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