Immunopharmacology in Autoimmune Diseases and Transplantation

  • Hans Erik Rugstad
  • Liv Endresen
  • Øystein Førre

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Immunology and Pathogenetic Mechanisms

    1. Front Matter
      Pages 1-1
    2. Robert Winchester
      Pages 3-14
    3. Kristian Waalen, Øystein Førre
      Pages 15-29
    4. Øystein Førre, Kristian Waalen, Jens Kjeldsen-Kragh, Dag Sørskaar, Ove J. Mellbye, Jacob B. Natvig
      Pages 31-44
    5. Jens Kjeldsen-Kragh, Alison Quayle, Catherine Kalvenes, Øystein Førre
      Pages 45-58
    6. Dag Sørskaar, Øystein Førre
      Pages 59-69
    7. Sudhir Gupta
      Pages 71-91
    8. Norman Talal
      Pages 93-99
  3. Pharmacology and General Therapeutic Principles of Immunomodulating Drugs

    1. Front Matter
      Pages 101-101
    2. Bruce W. Kirkham, Gabriel S. Panayi
      Pages 103-121
    3. Jean-François Bach
      Pages 123-126
    4. A. M. Denman, D. J. Denman, R. G. Palmer
      Pages 139-158
    5. Gilles Feutren, Beat von Graffenried
      Pages 159-173
    6. Yejun Zhao, Marie L. Foegh
      Pages 175-187
    7. Lucienne Chatenoud, Jean-François Bach
      Pages 189-203
    8. David C. Blakey
      Pages 205-216
    9. Jean-François Bach
      Pages 227-231
    10. Hans Erik Rugstad
      Pages 233-244
  4. Immunotherapy in Autoimmune Disease

    1. Front Matter
      Pages 261-261
    2. Alfonso Monereo, Munther Andrawes Khamashta, Juan José Vazquez, Graham Robert Vivian Hughes
      Pages 263-271
    3. P. A. Bacon, R. A. Luqmani, D. G. I. Scott, D. Adu
      Pages 273-290
    4. Martin Lombard, Roger Williams
      Pages 291-299
    5. J. L. Mahon, J. Dupre, C. R. Stiller
      Pages 301-311
    6. Rolf Nyberg-Hansen, Leif Gjerstad
      Pages 325-333
    7. Robert B. Nussenblatt
      Pages 335-343
    8. Mark S. Fradin, Marc D. Brown, Charles N. Ellis, Kevin D. Cooper, John J. Voorhees
      Pages 345-356
    9. Knut J. Berg, Tore Talseth
      Pages 357-367
  5. Immunotherapy in Organ and Bone Marrow Transplantation

    1. Front Matter
      Pages 379-379
    2. Luis Mieles, Robert L. Kormos, Leonard Makowka, Thomas E. Starzl
      Pages 381-396
    3. Dagfinn H. Albrechtsen
      Pages 397-408
  6. Back Matter
    Pages 409-420

About this book


This book incorporates the latest advances in immunopharmacological treatment. One objective has been to provide appropriate bridges between the basic sciences of immunology and pharmacology on the one hand and clinical medicine on the other. A further intention has been to emphasize those advances in immunology and pharmacology that are of clinical importance while retaining those facts that, while not new, remain clinically useful. The immunology section provides the necessary background for immunopharmacologi­ cal treatment. The chapters on individual cell types include normal surface markers, mode of activation, and activation markers and functions in health and disease. The chapters on pharmacology give comprehensive information on immunosuppressive drugs in regular use today, their biochemical and cellular mechanisms of action, pharmaco­ kinetics, dosage regimens, therapeutic responses, adverse reactions, and drug interactions and tolerance. In addition, certain therapeutic principles that are still in an experimental phase are described, for example, immunotoxins, thymic hormones, and interleukins. The book presents comprehensive information on various autoimmune diseases, the etiopathogenetic immune mechanisms where these are known, and the current possibilities for immunopharmacological intervention. The specific disease section also covers rare situations, fluctuations in disease patterns, and subgroups of patients and immunophar­ macological treatment in these situations. Altogether, the book represents a practical textbook for clinicians and advanced students who want to be updated on therapeutic principles with regard to autoimmune diseases and transplantation.


autoimmune disease autoimmunity diseases immunotherapy kidney lymphocytes pharmacology research steroids transplantation

Editors and affiliations

  • Hans Erik Rugstad
    • 1
  • Liv Endresen
    • 2
  • Øystein Førre
    • 3
  1. 1.Department of Clinical Pharmacology, The National HospitalUniversity of OsloOslo 1Norway
  2. 2.Institute of Clinical Biochemistry, The National HospitalUniversity of OsloOslo 1Norway
  3. 3.Oslo Sanitetsforening Rheumatism HospitalOslo 1Norway

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