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DNA Tumor Viruses

Oncogenic Mechanisms

  • Giuseppe Barbanti-Brodano
  • Mauro Bendinelli
  • Herman Friedman

Part of the Infectious Agents and Pathogenesis book series (IAPA)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Siegfried Scherneck, Jean Feunteun
    Pages 1-14
  3. Daniel T. Simmons
    Pages 27-50
  4. Paolo Monini, Laura de Lellis, Giuseppe Barbanti-Brodano
    Pages 51-73
  5. Michele Carbone, Paola Rizzo, Harvey I. Pass
    Pages 75-90
  6. Craig D. Woodworth, Joseph A. DiPaolo
    Pages 91-109
  7. Christa Cerni, Christian Seelos
    Pages 123-155
  8. Marie Annick Buendia, Pascal Pineau
    Pages 171-193
  9. Dario Di Luca, E. Caselli, E. Cassai
    Pages 281-293
  10. K. Radsak, H. Kern, B. Reis, M. Reschke, T. Mockenhaupt, M. Eickmann
    Pages 295-312
  11. Dario Di Luca, Riccardo Dolcetti
    Pages 313-326
  12. Nancy S. Sung, Joseph S. Pagano
    Pages 327-346
  13. Layla Karimi, Dorothy H. Crawford
    Pages 347-373
  14. Mauro Boiocchi, Riccardo Dolcetti, Valli de Re, Antonino Carbone, Annunziata Gloghini
    Pages 375-393
  15. Andrew J. Morgan
    Pages 395-419
  16. Back Matter
    Pages 421-428

About this book

Introduction

DNA tumor viruses have long been useful experimental models of carcinogenesis and have elucidated several important mechanisms of cell transformation. Re­ search in recent years has shown that human tumors have a multifactorial nature and that some DNA tumor viruses may playa key role in their etiology. The aim of this book is to assess our knowledge of DNA tumor viruses by reviewing animal models, mechanisms of transformation, association with human tumors, and possi­ bilities of prevention and control by vaccination. Animal models of tumor virology have contributed significantly to our under­ standing of the epidemiology and pathogenesis of virus-induced tumors. Bovine papillomaviruses induce papillomas in the intestine of cattle. The papillomas undergo a transition to carcinomas in cows feeding on bracken fern, which pro­ duces a toxin with radiomimetic and immunosuppressive functions. This example of cooperation between a virus and chemical carcinogens parallels the cooperative role of human papillomaviruses (HPVs) and herpes simplex virus type 2 (HSV-2) with environmental carcinogens in the pathogenesis of cervical cancer. Likewise, hepatocarcinomas appearing in woodchucks chronically infected by woodchuck hepatitis virus (WIN) provide strong support for the relationship between hepatitis B virus (HBV) infection and human hepatocellular carcinoma. Also, the fact that WIN DNA integrates closely to cellular oncogenes suggests a possible molecular mechanism for the tumorigenesis induced by HBV.

Keywords

Pathogene development protein tumorigenesis virus

Editors and affiliations

  • Giuseppe Barbanti-Brodano
    • 1
  • Mauro Bendinelli
    • 2
  • Herman Friedman
    • 3
  1. 1.Institute of Microbiology, School of MedicineUniversity of FerraraFerraraItaly
  2. 2.University of PisaPisaItaly
  3. 3.University of South FloridaTampaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4899-1100-1
  • Copyright Information Springer-Verlag US 1995
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-1102-5
  • Online ISBN 978-1-4899-1100-1
  • Series Print ISSN 1075-1289
  • Buy this book on publisher's site
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