© 1994

Mechanisms of Lymphocyte Activation and Immune Regulation V

Molecular Basis of Signal Transduction

  • Sudhir Gupta
  • William E. Paul
  • Anthony DeFranco
  • Roger M. Perlmutter

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Signaling by Antigen Receptors of B Cells

    1. Heinrich Flaswinkel, Peter Weiser, Kwang-Myong Kim, Michael Reth
      Pages 1-8
    2. Anthony L. DeFranco, Paul R. Mittelstadt, Jonathan H. Blum, Tracy L. Stevens, Debbie A. Law, Vivien W.-F. Chan et al.
      Pages 9-22
    3. John A. Taddie, Tamara R. Hurley, Bartholomew M. Sefton
      Pages 23-34
    4. Edward A. Clark, Ingolf Berberich, Stephen J. Klaus, Che-Leung Law, Svetlana P. Sidorenko
      Pages 35-43
  3. Signaling by Antigen Receptors of T Cells

    1. Arthur Weiss, Makio Iwashima, Bryan Irving, Nicolai S. C. van Oers, Theresa A. Kadlecek, David Straus et al.
      Pages 53-62
    2. Dan R. Littman, Craig B. Davis, Nigel Killeen, Hua Xu
      Pages 63-71
    3. Doreen Cantrell, M. Izquierdo Pastor, M. Woodrow
      Pages 73-79
    4. Lixin Zheng, Stefen A. Boehme, Jeffrey M. Critchfield, Juan Carlos Zuniga-Pflucker, Matthew Freedman, Michael J. Lenardo
      Pages 81-89
  4. Signaling Components of Lymphocytes

    1. Brett A. Premack, Phyllis Gardner
      Pages 91-102
    2. Robert L. Geahlen, Debra L. Burg
      Pages 103-109
    3. Brian Seed, Waldemar Kolanus, Charles Romeo, Ramnik Xavier
      Pages 111-119
    4. Roger M. Perlmutter, Steven J. Anderson
      Pages 121-130
    5. Anne L. Burkhardt, Sandra J. Saouaf, Sandeep Mahajan, Joseph B. Bolen
      Pages 131-141
    6. Steffan Ho, Luika Timmerman, Jeffrey Northrop, Gerald R. Crabtree
      Pages 167-173
  5. Signaling VIA Fc Receptors and Cytokine Receptors

    1. Henry Metzger, Byron Goldstein, Ute Kent, Su-Yau Mao, Clara Pribluda, Victor Pribluda et al.
      Pages 175-183
    2. David Brooks, Jeffrey V. Ravetch
      Pages 185-195

About this book


Signaling through antigen receptor initiates a complex series of events resulting in the activation of genes that regulate the development, proliferation and differentiation of lymphocytes. During the past few years, rapid progress has been made in understanding the molecular basis of signaling pathways mediated by antigen and cytokine receptors. These pathways involve protein tyrosine kinases which are coupled to downstream regulatory molecules, including small guanine nucleotide binding proteins (e. g. p21'OS), serine threonine kinases (e. g. , members of the ERK family), and a large group of transcription factors. More recently, there have been breakthroughs in elucidating the genetic defects underlying three X-linked primary immunodeficiency diseases in humans. This volume surveys aspects of these rapidly developing areas of research. The book is divided into 5 different sections. Section I deals with signaling pathways in B lymphocytes. It includes a contemporary assessment of B cell antigen receptor structures, and discussion of the role of Ig-a/lg-B polypeptides in linking the antigen receptor to intracellular signal transduction pathways. The role of accessory molecules in the regulation of signaling by the B cell antigen receptor is also considered. Section II adopts a similar approach to the analysis of the antigen receptor on T lymphocytes. The importance of specialized signaling motifs in the CD3 polypeptides, mechanisms whereby these motifs may interact with the lymphocyte-specific protein tyrosine kinases, and the downstream consequences of these interactions are reviewed. In addition, the role of antigen-induced apoptosis in the generation of immunological tolerance is discussed.


Antigen T cell apoptosis autoimmunity cytokine development immunodeficiency lymphocytes physiology

Editors and affiliations

  • Sudhir Gupta
    • 1
  • William E. Paul
    • 2
  • Anthony DeFranco
    • 3
  • Roger M. Perlmutter
    • 4
  1. 1.Department of MedicineUniversity of CaliforniaIrvineUSA
  2. 2.National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  3. 3.Department of Microbiology and ImmunologyUniversity of CaliforniaSan FranciscoUSA
  4. 4.Department of ImmunologyUniversity of WashingtonSeattleUSA

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