Diet and Cancer

Markers, Prevention, and Treatment

  • Maryce M. Jacobs

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Vitamin-Regulated Retinoblastoma Tumor Suppressor Gene Expression in Leukemic Cells

    1. Andrew Yen, Tracy French, Karen Russell, Susi Varvayanis, Mary Forbes
      Pages 1-18
  3. Retinoic Acid Suppresses Human Papillomavirus Type 16 (HPV16)-Mediated Transformation of Human Keratinocytes and Inhibits the Expression of the HPV16 Oncogenes

    1. Kim E. Creek, G. Ronald Jenkins, Mohammad A. Khan, Ayse Batova, John R. Hodam, William H. Tolleson et al.
      Pages 19-35
  4. Interactions Between Retinoic Acid and Protein Kinase C in Induction of Melanoma Differentiation

  5. Racial and Ethnic Issues in Diet and Cancer Epidemiology

  6. Dietary Modulation of Oxidative DNA Damage

    1. Zora Djuric, Silvana Martino, Lance K. Heilbrun, Ronald W. Hart
      Pages 71-83
  7. Carbohydrate Tumor Marker: Basis for a Simple Test for Colorectal Cancer

    1. Abulkalam M. Shamsuddin, Kosaku Sakamoto
      Pages 85-99
  8. Chemical and Mutagenic Specificities of Polycyclic Aromatic Hydrocarbon Carcinogens

    1. Anthony Dipple, Kimmo Peltonen, S. Chau Cheng, Helen Ross, C. Anita H. Bigger
      Pages 101-112
  9. Inhibition of Tumorigenesis by Chemicals from Garlic and Tea

    1. Chung S. Yang, Zhi-Yuan Wang, Jun-Yan Hong
      Pages 113-122
  10. Cancer Chemoprevention by Green Tea Components

    1. Hasan Mukhtar, Santosh K. Katiyar, Rajesh Agarwal
      Pages 123-134
  11. Potential Role of Dietary Isoflavones in the Prevention of Cancer

    1. Stephen Barnes, Greg Peterson, Clinton Grubbs, Ken Setchell
      Pages 135-147
  12. Carcinogen-DNA and Protein Adducts as Intermediate Biomarkers for Human Chemoprotection Trials

    1. John D. Groopman, Bill D. Roebuck, Thomas W. Kensler
      Pages 149-160
  13. Cytokines, Iron Homeostasis, and Cancer

    1. Frank M. Torti, Suzy V. Torti
      Pages 161-170
  14. Evidence for Nutrient Modulation of Tumor Phenotype: Impact of Tyrosine and Phenylalanine Restriction

    1. Catherine A. Elstad, Gary G. Meadows, Cheryl J. Aslakson, Jean R. Starkey
      Pages 171-183
  15. Possible Role of Neuropeptide Y in Experimental Cancer Anorexia

    1. William T. Chance, Ambikaipakan Balasubramaniam, Sulaiman Sheriff, Josef E. Fischer
      Pages 185-201
  16. Metabolic Alterations and Lactate Overproduction in Insulin-Resistant States

  17. Poster Abstracts

    1. Front Matter
      Pages 211-215
    2. L. J. Jenski, L. K. Sturdevant, W. D. Ehringer, A. C. Dumaual, W. Stillwell
      Pages 220-220
    3. I. Vucenik, M. Bansal, A. M. Shamsuddin
      Pages 224-224
    4. P. J. Deeter, P. S. Goldstein, T. D. Walsh
      Pages 227-227
    5. G. Lozovik, M. Shlyankevich, A. Sergeev
      Pages 229-229
    6. M. F. Locniskar, S. M. Fischer, M. A. Belury
      Pages 231-231
    7. N. F. Boyd, L. J. Martin, M. Noffel, G. Lockwood, D. L. Tritchler
      Pages 234-234
    8. C. J. Grubbs, T. L. Casebolt, I. Eto, M. M. Juliana, L. M. Whitaker, G. J. Canfield et al.
      Pages 235-235
    9. M. Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, G. Stotzky
      Pages 237-237
    10. L. Kiremidjian-Schumacher, M. Roy, H. I. Wishe, M. W. Cohen, G. Stotzky
      Pages 238-238
    11. J. K. Christman, G. Sheikhnejad, M. Dizik, S. Abileah, E. Wainfan
      Pages 239-239
    12. C. A. Redlich, S. N. Mohr, S. T. Mayne, W. W. Merrill, D. Carter, M. R. Cullen
      Pages 241-241
    13. B. P. Fine, K. A. Hansen, T. N. Denny, T. R. Walters
      Pages 242-242
    14. J. K. Tillotson, L. A. Cohen, Z. Ronai
      Pages 243-243
    15. S. Wei, V. Episkopou, R. Piantedosi, M. E. Gottesman, E. J. Robertson, W. S. Blaner
      Pages 245-245

About this book


The American Institute for Cancer Research (AICR) sponsored its third annual confer­ ence on nutrition and cancer. The theme was "Diet and Cancer: Markers, Prevention, and Treatment. " The conference was held October 29-30, 1992 at the Ritz Carlton Hotel in McLean, Virginia. This proceedings contains chapters from the platform presentations and abstracts from the poster presentations. Several chapters address each of four session topics: Retinoids as Differentiation Agents in Cancer Therapy, Biological Markers of Cancer Risk, Chemoprevention of Cancer by Non-Nutrients in Foods, and Nutritional Problems and Support in the Treatment of Cancer. The first three chapters discuss in detail different mechanisms by which retinoids influence differentiation and provide evidence to support their use in cancer therapy. In vivo and in vitro studies show the effects of retinoic acid (RA) on tumorigenicity and cellu­ lar/molecular events. A synopsis of data showing the involvement of the retinoblastoma (RB) gene in HL-60 cell differentiation induced by RA and 1,2S-dihydroxy vitamin D3 (VD) is presented. In SCID (severe combined immunodeficiency) mice injected with HL-60 3 human leukemia cells and gavaged daily with RA, the number of tumor sites and number of mice with tumors are reduced. All trans-RA induces myeloid differentiation in HL-60 cells. Similarly, VD3 induces HL-60 monocytic differentiation. In both cases an early down regulation of retinoblastoma (RB) gene expression precedes the differentiation.


Carcinom Colon DNA Translation Vitamin A Vitamin D cancer gene expression proteins

Editors and affiliations

  • Maryce M. Jacobs
    • 1
  1. 1.American Institute for Cancer ResearchUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1994
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-0941-1
  • Online ISBN 978-1-4899-0939-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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