Sensory Nerves and Neuropeptides in Gastroenterology

From Basic Science to Clinical Perspectives

  • Marcello Costa
  • Calogero Surrenti
  • Sergio Gorini
  • Carlo Alberto Maggi
  • Alberto Meli

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)

Table of contents

  1. Front Matter
    Pages i-x
  2. M. Costa, S. Brookes, P. Steele, J. Vickers
    Pages 17-27
  3. G. J. Dockray, E. R. Forster, S. M. Louis
    Pages 53-62
  4. D. Regoli, N.-E. Rhaleb, N. Rouissi, C. Tousignant, D. Jukic, C. Drapeau
    Pages 63-74
  5. Helen E. Raybould, Peter Holzer, Gerard Thiefin, Helge H. Holzer, Masashi Yoneda, Yvette F. Tache
    Pages 109-127
  6. Daniela Renzi, Stefano Evangelista, Paola Mantellini, Calogero Surrenti
    Pages 129-135
  7. G. Coruzzi, M. Adami, G. Bertaccini
    Pages 157-165
  8. Paolo Procacci, Marco Maresca, Riccardo Maria Cersosimo
    Pages 175-181
  9. Gervais Tougas, Hans-D. Allescher, John Dent, Edwin E. Daniel
    Pages 199-211
  10. Carlo Alberto Maggi, Sandro Giuliani, Paolo Santicioli, Riccardo Patacchini, Elvar Theodorsson, Damiano Turini et al.
    Pages 213-217
  11. G. Soldani, C. Belloli, P. Ormas, G. Coruzzi, D. R. Brown, C. Beretta
    Pages 219-232
  12. Elvar Theodorsson, Bengt Smedfors, Per Hellström, Olof Söder, Andreas Aly, Alexandru Musat et al.
    Pages 233-240
  13. Stefano Manzini, Manuela Tramontana, Francesca Perretti
    Pages 241-248
  14. Sandro Giuliani, Carlo Alberto Maggi, Riccardo Patacchini, Paolo Santicioli, Damiano Turini, Gabriele Barbanti et al.
    Pages 249-252
  15. P. W. Mantyh, M. Catton, J. E. Maggio, S. R. Vigna
    Pages 253-283
  16. Alessandro Casini, Irmgard Th. Lippe, Stefano Evangelista, Pierangelo Geppetti, Paolo Santicioli, Carmelo Urso et al.
    Pages 285-293
  17. S. Giancane, M. Bernardi, F. Trevisani, Paola Emanuela D’Intino, Maria Rosa Tamé, A. Gasbarrini et al.
    Pages 295-300
  18. Back Matter
    Pages 307-308

About this book


In the past 15 years much evidence has accumulated which indicates the paramount importance of sensory nerves in reg­ ulating functions of the gastrointestinal tract. In parallel, the attention of researchers in this field has been increas­ ingly attracted to the role played by neuropeptides in the normal and diseased gut. Basic research on the peculiar properties of capsaicin, the pungent ingredient from plants of the genus Capsicum, has allowed the gap between these two areas of research to be bridged. Sincethen, the study of gut afferents and neuropeptides has become more and more interconnected and recognized as a major avenue to understand­ ing the pathophysiology of various human diseases. It is widely recognized that a certain subset of primary afferents synthesize, store and release neuropeptides (such as tachykin­ nins and calcitonin gene-related peptide) from their central and peripheral endings, the latter being widely distributed in the alimentary canal and related organs (liver, pancreas). The First International Meeting on Sensory Nerves and Neuropeptides in Gastroenterology, held in Florence from December 4-5, 1989, sponsored and organized by Fondazione Internazionale Menarini, aimed to focus the current status of research in this field. The contributions presented at the meeting and in this book delineate a suggestive scenario in which sensory nerves of the gut, and the multiple messages they carry through the release of neuropeptides, are to be considered as a major target for the development of new drugs potentially useful in a number of diseases of the gastro­ intestinal tract.


Ethanol Flow Nervous System Opioid neurons neuropeptides pathophysiology physiology

Editors and affiliations

  • Marcello Costa
    • 1
  • Calogero Surrenti
    • 2
  • Sergio Gorini
    • 3
  • Carlo Alberto Maggi
    • 4
  • Alberto Meli
    • 4
  1. 1.Flinders University of South AustraliaAdelaideAustralia
  2. 2.University of FlorenceFlorenceItaly
  3. 3.Fondazione Internazionale MenariniFlorenceItaly
  4. 4.A. Menarini PharmaceuticalsFlorenceItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-0746-2
  • Online ISBN 978-1-4899-0744-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology