Enkephalins and Endorphins

Stress and the Immune System

  • Nicholas P. Plotnikoff
  • Robert E. Faith
  • Anthony J. Murgo
  • Robert A. Good

Table of contents

  1. Front Matter
    Pages i-ix
  2. Enkephalins-Endorphins: Stress and the Immune System

    1. N. P. Plotnikoff, A. J. Murgo, R. E. Faith, R. A. Good
      Pages 1-2
  3. Stress and the Immune System

    1. Christopher J. Evans, Elizabeth Erdelyi, Jack D. Barchas
      Pages 3-15
    2. L. Giorgio Roda, Gianna Roscetti, Roberta Possenti, Francesca Venturelli, Fabrizio Vita
      Pages 17-33
    3. Martin R. Cohen, David Pickar, Michel Dubois, Robert M. Cohen
      Pages 35-45
    4. Peter Farrell, Anthony Gustafson
      Pages 47-57
    5. Ziad Kronfol, Janet Schlechte
      Pages 69-80
    6. Ian S. Zagon, Patricia J. Mclaughlin
      Pages 81-100
    7. James W. Lewis, Yehuda Shavit, Fredricka C. Martin, Gregory W. Terman, Robert P. Gale, John C. Liebeskind
      Pages 101-108
    8. F. Berkenbosch, C. J. Heijnen, G. Croiset, C. Revers, R. E. Ballieux, R. Binnekade et al.
      Pages 109-118
  4. Regulatory Circuits of the Immune, Endocrine and Nervous System

    1. George S. Solomon, Neil Kay, John E. Morley
      Pages 129-144
    2. V. Kluša, R. Muceniece, Š. Svirskis, E. Kukaine, M. Ratkeviča, G. Rosenthal et al.
      Pages 145-157
    3. George C. Tsokos, James E. Balow
      Pages 159-171
    4. Oscar J. Pung, Anne N. Tucker, Michael I. Luster
      Pages 173-187
  5. Effects of Enkephalins/Endorphins and Related Substances on Specific Immune Functions

    1. Anthony J. Murgo, Robert E. Faith, Nicholas P. Plotnikoff
      Pages 221-239
    2. Eike G. Fischer, Nora E. Falke
      Pages 263-272
    3. Hulon W. McCain, Ira B. Lamster, Joanne Bilotta
      Pages 273-287
    4. Robert Donahoe, John Madden, Felicia Hollingsworth, David Shafer, Arthur Falek
      Pages 289-302
    5. Gabriella Foris, George A. Medgyesi, Jozsef I. Szekely
      Pages 303-320
    6. H. D. Whitten, K. Y. Tsang, P. Arnaud, N. K. Khansari, H. H. Fudenberg
      Pages 337-346
    7. Hikmet Koyuncuoğlu, Mehmet Güngör
      Pages 347-365
    8. S. Lori Brown, Sei Tokuda, Linda C. Saland, Dennis E. Van Epps
      Pages 367-386
  6. Early Clinical Trials of Methionine Enkephalin (in Vivo)

    1. N. P. Plotnikoff, G. C. Miller, S. Solomon, R. E. Faith, L. Edwards, A. J. Murgo
      Pages 399-405
    2. N. P. Plotnikoff, S. Solomon, J. L. Valentine, M. Fesen, R. E. Faith, L. Edwards et al.
      Pages 407-416
    3. N. P. Plotnikoff, G. C. Miller, S. Solomon, R. E. Faith, L. Edwards, A. J. Murgo
      Pages 417-424
    4. N. P. Plotnikoff, J. Wybran, N. F. Nimeh, G. C. Miller
      Pages 425-429
    5. Robert E. Faith, Anthony J. Murgo, Nicholas P. Plotnikoff
      Pages 431-433
  7. Back Matter
    Pages 435-447

About this book


Is this a time for a sleeping giant to rise? We have known since study of the lymphocyte and plasma cells really began in earnest in the early 1940's that the pituitary adrenal axis under intimate control of the hypothalamus could influence immunological functions profoundly. We have also known for at least 20 years in my recollection that female sex hor­ mones can maximize certain immunity functions while male sex hormones tend to suppress many immunological reactions. The thyroid hormones accelerate antibody production while at the same time sp~eding up de­ gradation of antibodies and immunoglobulins and thyroidectomy decreases the rate of antibody production. Further, much evidence has accumulated indicating that the brain, yes even the mind, can influence in significant ways susceptibility to infections, cancers and to development of a variety of autoimmune diseases. More than 20 years ago, my colleagues and I convinced ourselves, if no one else, that hypnosis can exert major in­ fluences on the effector limb of the classical atopic allergic reactions. We showed with Aaron Papermaster that the Prausnitz-Kustner reaction may be greatly inhibited, indeed largely controlled, by post-hypnotic suggestion. And it was not even necessary for us to publish our discovery because scientists in John Humphrey's laboratory at Mill Hill Research Center in London had beaten us to the punch. They described hypnotic control of both the PK reaction and delayed allergic reactions to tuberculin by hypnosis.


Depression Nervous System brain endogenous opioid peptides interaction neuropeptides receptor schizophrenia stress tumor

Editors and affiliations

  • Nicholas P. Plotnikoff
    • 1
  • Robert E. Faith
    • 2
  • Anthony J. Murgo
    • 3
  • Robert A. Good
    • 4
  1. 1.Oral Roberts UniversityTulsaUSA
  2. 2.University of HoustonHoustonUSA
  3. 3.West Virginia UniversityMorgantownUSA
  4. 4.University of South FloridaSt. PetersburgUSA

Bibliographic information

Industry Sectors
Health & Hospitals