© 1996

Mechanisms of Lymphocyte Activation and Immune Regulation VI

Cell Cycle and Programmed Cell Death in the Immune System

  • Sudhir Gupta
  • J. John Cohen

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 406)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Cell Cycle and Signaling Pathways in Apoptosis

    1. Sudhir Gupta
      Pages 1-9
    2. J. John Cohen
      Pages 11-20
    3. Robert A. Schlegel, Melissa Callahan, Stephen Krahling, Deepti Pradhan, Patrick Williamson
      Pages 21-28
    4. Seamus J. Martin, Gustavo P. Amarante-Mendes, Douglas R. Green
      Pages 29-37
    5. Steven J. Chmura, Edwardine Nodzenski, Mary A. Crane, Subbulakshmi Virudachalam, Dennis E. Hallahan, Ralph R. Weichselbaum et al.
      Pages 39-55
    6. N. Jan Chalupny, Liqing Zhu, Xue-zhong Yu, Claudio Anasetti
      Pages 57-67
    7. Jonathan W. Uhr, Radu Marches, Emil Racila, Thomas F. Tucker, Robert Hsueh, Nancy E. Street et al.
      Pages 69-74
  3. Apoptosis-Regulating Genes

    1. Gabriel Nuñez, Ramon Merino, Philip L. Simonian, Didier A. M. Grillot
      Pages 75-82
    2. John C. Reed, Hongbin Zha, Christine Aime-Sempe, Shinichi Takayama, Hong-Gang Wang
      Pages 99-112
    3. Vishva M. Dixit
      Pages 113-117
    4. Shigekazu Nagata
      Pages 119-124
    5. Giovina Ruberti, Isabella Cascino, Giuliana Papoff, Adriana Eramo
      Pages 125-134
  4. Apoptosis in B Cells

    1. John Gordon, Christopher D. Gregory, Gillian Grafton, John D. Pound
      Pages 139-144
    2. Robert F. Ashman, David Peckham, Laura L. Stunz
      Pages 145-154
    3. Karen A. Jacobsen, Eustache Paramithiotis, Don L. Ewert, Michael J. H. Ratcliffe
      Pages 155-165
    4. Philip Kuo, Daniel Michael, Boaz Tadmor, Betty Diamond
      Pages 167-176
    5. Thomas L. Rothstein, Linda C. Foote, Thomas J. Schneider, Gavin M. Fischer, Bruce A. Jacobson, David H. Lynch et al.
      Pages 177-189

About this book


Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.


T cell Thymus apoptosis diseases insects lymphocytes macrophages programmed cell death proteins virus

Editors and affiliations

  • Sudhir Gupta
    • 1
  • J. John Cohen
    • 2
  1. 1.University of California, IrvineIrvineUSA
  2. 2.University of Colorado Health Sciences CenterDenverUSA

Bibliographic information

Industry Sectors
Health & Hospitals


`This book is a valuable addition to the literature.'
Quarterly Review of Biology, March 1998