Botulinum and Tetanus Neurotoxins

Neurotransmission and Biomedical Aspects

  • Bibhuti R. DasGupta

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Introduction

    1. Bibhuti R. DasGupta
      Pages 1-4
  3. An Overview

  4. Neurotrophic Factors and Denervation

    1. Moses V. Chao, Julie Huber, Margaret Berg, Marta Benedetti, Curt Horvath, Barbara Hempstead
      Pages 17-24
    2. Bernard Bizzini, Mohamed Khiri, Martine Carlotti
      Pages 31-43
    3. Dušan Šuput, Jernej Dolinšek, Robert Frangež, Franci Demšar
      Pages 63-67
  5. Neurotransmitter Secretion; Poisoning Models

    1. Eric A. Schwartz
      Pages 69-70
    2. Thomas F. J. Martin, Jane H. Walent, Bruce W. Porter, Jesse C. Hay
      Pages 87-93
    3. Alan Morgan, Isabelle Cenci de Bello, Ulrich Weller, J. Oliver Dolly, Robert D. Burgoyne
      Pages 95-104
    4. Paul D. Wagner, Ngoc-Diep Vu, You Neng Wu
      Pages 105-115
    5. C. Solsona, E. López-Alonso, J. Blasi, J. Canaves, J. Canals, M. Arribas et al.
      Pages 143-151
  6. Endocytosis, Endosomal Processing

    1. Michela Matteoli, Pietro De Camilli
      Pages 153-163
    2. James M. Lenhard, Maria I. Colombo, Michael Koval, Guangpu Li, Luis S. Mayorga, Philip D. Stahl
      Pages 179-190
  7. Mechanism of Action

    1. Anthony C. Ashton, Anton M. de Paiva, Bernard Poulain, Ladislav Tauc, J. Oliver Dolly
      Pages 191-213
    2. Cara-Lynne Schengrund, Bibhuti R. DasGupta, Nancy J. Ringler
      Pages 215-219
    3. Giampietro Schiavo, Ornella Rossetto, Giovanna Ferrari, Cesare Montecucco
      Pages 221-230
    4. H. Bigalke, F. Bartels, T. Binscheck, E. Erdal, G. Erdmann, U. Weller et al.
      Pages 241-250
    5. Robert V. Considine, Lance L. Simpson, Joseph R. Sherwin
      Pages 251-254
    6. Philip Lazarovici, Alexander Fedinec, Bernard Bizzini
      Pages 255-264
    7. Alexander A. Fedinec, Teresa Duda, Bernard Bizzini, Nigel G. F. Cooper, Rameshwar K. Sharma
      Pages 265-272
    8. Dennis L. Leatherman, John L. Middlebrook
      Pages 311-316
    9. Noriko Yokosawa, Kouichi Kimura, Kayo Tsuzuki, Nobuhiro Fujii, Bunei Syuto, Keiji Oguma
      Pages 317-320
    10. Woon Ling Chan, Dorothea Sesardic, Clifford C. Shone
      Pages 337-339
  8. Structure-Function Relationship

    1. Bernard Poulain, Ulrich Weller, Thomas Binz, Heiner Niemann, Anton de Paiva, J. Oliver Dolly et al.
      Pages 345-360
    2. Heiner Niemann, Thomas Binz, Oliver Grebenstein, Hisao Kurazono, Arno Kalkuhl, Shinji Yamasaki et al.
      Pages 361-375
  9. Structure

    1. Raymond C. Stevens
      Pages 393-395
    2. M. F. Schmid, J. P. Robinson, B. R. DasGupta
      Pages 397-399
    3. Masafumi Nukina, Yumi Mochida, Tsutomu Miyata, Sumiko Sakaguchi, Genji Sakaguchi
      Pages 401-404
  10. Genetics

    1. Nobuhiro Fujii, Kouichi Kimura, Kayo Tsuzuki, Noriko Yokosawa, Keiji Oguma
      Pages 405-420
  11. Antigenic Structure, Antibody, Immunity

    1. Domingo F. Giménez, Juan A. Giménez
      Pages 421-431
    2. Bassam Hallis, Sarah Fooks, Clifford Shone, Peter Hambleton
      Pages 433-436
    3. Shunji Kozaki, Teiichi Nishiki, Shoji Nakaue, Yoichi Kamata, Genji Sakaguchi
      Pages 437-448
    4. Gerri M. Ransom, Wei H. Lee, Elisa L. Elliot, Charles P. Lattuada
      Pages 449-461

About this book


Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during this time. A comprehensive symposium 4 on C. botulinum neurotoxins has been organized at Ft. Detrick. International conferences on tetanus have been held regularly under the auspices of the Wodd Health Organization. One or maximally two days of these meetings have been devoted to tetanus toxin and its actions whereas the sponsor and the majority of the participants have been interested mainly in epidemiology, prevention and treatment of tetanus as a disease (see refs. 5,6). Some aspects of clostridial neurotoxins have been addressed in the context of bacterial toxins, in particular in the biennial European workshops. 1-3,7,8 The Madison meeting differed from the previous ones in three aspects. First, it covered both tetanus and botulinum neurotoxins. The fusion was justified because of their huge similarities in primary structure, in their mode of action and in their cellular targets. Second, the meeting was not limited to toxins but drew some lines on which modern neurobiology might proceed.


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Editors and affiliations

  • Bibhuti R. DasGupta
    • 1
  1. 1.University of WisconsinMadisonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-9544-8
  • Online ISBN 978-1-4757-9542-4
  • Buy this book on publisher's site
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