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Biology and Physiology of the Blood-Brain Barrier

Transport, Cellular Interactions, and Brain Pathologies

  • Pierre-Olivier Couraud
  • Daniel Scherman

Part of the Advances in Behavioral Biology book series (ABBI, volume 46)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introductory Overviews

  3. Physiological Transports through the Blood-Brain Barrier

    1. Richard F. Keep, Walter Stummer, Jianming Xiang, A. Lorris Betz
      Pages 11-16
    2. Hameed Al-Sarraf, Kevin A. Smart, Malcolm B. Segal, Jane E. Preston
      Pages 27-33
    3. Ivanka D. Markovic, Zoran B. Redzic, Suzana S. Jovanovic, Dusan M. Mitrovic, Ljubisa M. Rakic
      Pages 35-39
    4. S. S. Jovanovic, Z. B. Redzic, I. D. Markovic, D. M. Mitrovic, Lj. M. Rakic
      Pages 41-45
    5. Richard F. Keep, Jianming Xiang, A. Lorris Betz
      Pages 47-50
    6. Laurence Descamps, Marie-Pierre Dehouck, Gérard Torpier, Roméo Cecchelli
      Pages 51-54
    7. H. S. Sharma, K. Sanderson, E.-L. Glämsta, Y. Olsson, F. Nyberg
      Pages 63-68
    8. Sarah A. Williams, Thomas J. Abbruscato, Lajos Szabo, Robin Polt, Victor Hruby, Thomas P. Davis
      Pages 69-77
    9. Holger Gerhardt, Stefan Liebner, Hartwig Wolburg
      Pages 79-81
  4. Blood-Brain Barrier and Drug Delivery to the Brain

    1. Kenneth R. Davies, Grace Richardson, Wendy Akmentin, Virgil Acuff, Joseph D. Fenstermacher
      Pages 83-91
    2. Uwe Kniesel, Werner Risau, Hartwig Wolburg
      Pages 93-95
    3. P. Brust, S. Matys, J. Wober, A. Friedrich, R. Bergmann, B. Ahlemeyer
      Pages 109-115
    4. Evangeline Priya Eddy, Roman A. Olearchyk, Frederick M. Ryan, Timothy K. Hart, Philip L. Smith
      Pages 125-136
    5. Barbro B. Johansson, Irena Westergren, Claes Nordborg
      Pages 137-141
    6. M. P. Dehouck, B. Dehouck, L. Fenart, R. Cecchelli
      Pages 143-146
    7. Joachim Wegener, Helmut Franke, Stephan Decker, Martin Erben, Hans-Joachim Galla
      Pages 147-152
    8. Ursula Gath, Ansgar Hakvoort, H.-J. Galla
      Pages 153-158
    9. Z. B. Redzic, I. D. Markovic, S. S. Jovanovic, D. M. Mitrovic, Lj. M. Rakic
      Pages 159-164
    10. H. Patel, J. W. Hopewell
      Pages 165-167
  5. Multidrug Resistance P-Glycoprotein at the Blood-Brain Barrier

    1. Edith Beaulieu, Michel Demeule, Diana A. Averill-Bates, Richard Béliveau
      Pages 171-174
    2. Delphine Lechardeur, Pierre Wils, Bertrand Schwartz, Daniel Scherman
      Pages 175-183
    3. B. Joly, O. Fardel, V. Lécureur, C. Chesné, C. Puozzo, A. Guillouzo
      Pages 191-196
    4. Sandrine Desrayaud, Michel Lemaire
      Pages 197-204
    5. M. A. Barrand, K. Robertson, S. F. von Weikersthal, D. Horwell
      Pages 205-207
  6. Signal Transduction in Brain Endothelial Cells

  7. Interactions—Leukocytes-Brain Endothelial Cells

    1. Minoru Tomita, Yasuo Fukuuchi, Norio Tanahashi, Masahiro Kobari, Hidetaka Takeda, Masako Yokoyama et al.
      Pages 253-261
    2. Lucienne Juillerat-Jeanneret, Jun-ichi Murata, Emanuela Felley-Bosco, Sally Betz Corradin
      Pages 263-269
    3. Charles-Félix Calvo, Michel Mallat
      Pages 271-277
    4. P. M. G. Munro, L. A. McLaughlin-Borlace, G. Pryce, N. L. Occleston, J. Greenwood
      Pages 279-284
    5. Christian Fédérici, Luc Camoin, Maurice Hattab, Donny Strosberg, Pierre-Olivier Couraud
      Pages 293-297
    6. R. M. McCarron, Y. Yoshihide, M. Spatz, J. Hallenbeck
      Pages 299-302
    7. S. D. Bamforth, H. M. A. Towler, S. L. Lightman, J. Greenwood
      Pages 303-309

About this book

Introduction

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho­ logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu­ dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.

Keywords

Nervous System Pathologie development neuroscience physiology

Editors and affiliations

  • Pierre-Olivier Couraud
    • 1
  • Daniel Scherman
    • 2
  1. 1.Institut Cochin de Génétique MoléculaireParisFrance
  2. 2.CNRS-Rhône-Poulenc RorerVitry sur SeineFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-9489-2
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-9491-5
  • Online ISBN 978-1-4757-9489-2
  • Series Print ISSN 0099-6246
  • Buy this book on publisher's site
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