© 1996

Biological Reactive Intermediates V

Basic Mechanistic Research in Toxicology and Human Risk Assessment

  • Robert Snyder
  • I. Glenn Sipes
  • David J. Jollow
  • Terrence J. Monks
  • James J. Kocsis
  • George F. Kalf
  • Helmut Greim
  • Charlotte M. Witmer

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 387)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Session I

    1. Daniel Mansuy, Patrick M. Dansette
      Pages 1-6
    2. F. Peter Guengerich, Yune-Fang Ueng, Bok-Ryang Kim, Sophie Langouet, Brian Coles, Rajkumar S. Iyer et al.
      Pages 7-15
    3. Thomas Friedberg, Bettina Löllmann, Roger Becker, Romy Holler, Michael Arand, Franz Oesch
      Pages 17-24
    4. Iosif Ioannidis, Thomas Volk, Herbert de Groot
      Pages 25-30
  3. Session II

    1. Yoichi Osawa, Kashime Nakatsuka, Mark S. Williams, James T. Kindt, Mikiya Nakatsuka
      Pages 37-45
    2. Jack A. Hinson, Dean W. Roberts, N. Christine Halmes, Jennifer D. Gibson, Neil R. Pumford
      Pages 47-55
    3. Axel Knebel, Mihail Iordanov, Hans J. Rahmsdorf, Peter Herrlich
      Pages 57-62
    4. Kerstin N. Schmidt, Paul Amstad, Peter Cerutti, Patrick A. Baeuerle
      Pages 63-68
    5. Steven Xanthoudakis, Tom Curran
      Pages 69-75
    6. Judith M. Müller, Michael A. Cahill, Alfred Nordheim, Patrick A. Baeuerle
      Pages 77-84
  4. Session III

    1. Hyoung-Sook Park, Sean O’Connell, Saul Shupack, Edward Yurkow, Charlotte M. Witmer
      Pages 85-96
    2. Teresa G. Hastings, David A. Lewis, Michael J. Zigmond
      Pages 97-106
    3. U. Zanelli, P. Puccini, D. Acerbi, P. Ventura, P. G. Gervasi
      Pages 107-111
    4. Erna Hissink, Ben van Ommen, Jan J. Bogaards, Peter J. van Bladeren
      Pages 129-133

About this book


Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam­ ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi­ cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.


Oxidation biochemistry cytochrome P450 dopamine enzymes metabolism neurotoxicity proteins

Editors and affiliations

  • Robert Snyder
    • 1
  • I. Glenn Sipes
    • 2
  • David J. Jollow
    • 3
  • Terrence J. Monks
    • 4
  • James J. Kocsis
    • 5
  • George F. Kalf
    • 5
  • Helmut Greim
    • 6
  • Charlotte M. Witmer
    • 1
  1. 1.Environmental and Occupational Health Sciences InstituteRutgers UniversityPiscatawayUSA
  2. 2.University of ArizonaTusconUSA
  3. 3.Medical University of South CarolinaCharlestonUSA
  4. 4.University of TexasAustinUSA
  5. 5.Thomas Jefferson UniversityPhiladelphiaUSA
  6. 6.GSF Institute of ToxicologyTechnical UniversityMunichGermany

Bibliographic information

  • Book Title Biological Reactive Intermediates V
  • Book Subtitle Basic Mechanistic Research in Toxicology and Human Risk Assessment
  • Editors Robert R. Snyder
    James J. Kocsis
    I. Glenn Sipes
    George F. Kalf
    David J. Jollow
    Helmut Greim
    Terrence J. Monks
    Charlotte M. Witmer
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-306-45197-3
  • Softcover ISBN 978-1-4757-9482-3
  • eBook ISBN 978-1-4757-9480-9
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages XIV, 462
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Oncology
    Biochemistry, general
  • Buy this book on publisher's site
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