New Vaccines and Chemotherapy

1. Quality Control, Potency, and Standardization of Viral Vaccines

   1. Secretory IgA Antibody Responses after Immunization with Inactivated and Live Poliovirus Vaccine

      • L. Mellander, B. Carlsson, L. Å. Hanson, F. Jalil, A. L. van Wezel, S. Zaman

      Pages 209-215

2. Antiviral Chemotherapy

   1. Front Matter

      Pages 217-217

      PDF

   2. Nucleoside Analogues in the Chemotherapy of Viral Infections

      • Erik De Clercq

      Pages 219-232

   3. New Analogues to Acyclovir with Increased Potency to Herpes Viruses

      • A. Paul Fiddian

      Pages 233-240

   4. Carrier-Mediated Antiviral Therapy

      • M. Kende, D. J. Gangemi, W. Lange, D. A. Eppstein, J. Kreuter, P. G. Canonico

      Pages 241-264

   5. Synthetic Antiphytoviral Substances

      • G. Schuster

      Pages 265-283

   6. Chemotherapy of Plant Virus Infections

      • A. J. Hansen

      Pages 285-299

3. Back Matter

   Pages 301-306

   PDF

Viral Vaccines Joseph L. Melnick As with history in general, the history of vaccines needs to be reexamined and updated. My task is to look back to see what has been successful and to look forward to see what remains to be accomplished in the prevention of viral diseases by vaccines. Also, I shall refer to the pertinent material discussed at two recent conferences of the Institute of Medicine, National Academy of Sciences, on virus vaccines under development and their target populations in the United States (1985b) and in developing countries (1986). These reports, plus a third on Vaccine Supply and Innovation (1985a), should be required reading for all those in both the public and the private sector who have a responsibility or interest in vaccines for the prevention of human disease. It has been through the development and use of vaccines that many viral diseases have been brought under control. The vaccines consist either of infectious living attenu­ ated viruses or of noninfectious killed viruses or subviral antigens. When we look at the record, it is the live vaccines that have given the great successes in controlling diseases around the world. Examples are smallpox, yellow fever, poliomyelitis, measles, mumps, and rubella.

• Antigen
• chemotherapy
• development
• diseases
• lake
• research
• vaccine
• virology
• virus

• University of Montreal, Montreal, Canada

  Edouard Kurstak

• University of Alberta, Edmonton, Canada

  R. G. Marusyk

• Centers for Disease Control, Atlanta, USA

  F. A. Murphy

• Institute of Molecular and Cellular Biology, Strasbourg, France

  M. H. V. Regenmortel

Policies and ethics