Antimicrobial Resistance

A Crisis in Health Care

  • Donald L. Jungkind
  • Joel E. Mortensen
  • Henry S. Fraimow
  • Gary B. Calandra

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 390)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Christine C. Sanders, W. Eugene Sanders Jr.
    Pages 15-23
  3. David M. Livermore
    Pages 25-47
  4. J. J. Hilliard, H. M. Krause, J. I. Bernstein, J. A. Fernandez, V. Nguyen, K. A. Ohemeng et al.
    Pages 59-69
  5. Henry S. Fraimow, David M. Shlaes
    Pages 81-95
  6. Henry S. Fraimow, Donald L. Jungkind
    Pages 97-107
  7. Joel E. Mortensen, Thomas McDowell
    Pages 109-117
  8. Anthony L. Ferraro, Joel E. Mortensen, Deborah L. Blecker, Chanhpheng Phengvath
    Pages 119-121
  9. Haitham Tumah, John Woodwell, Ashwin Chatwani, Allan Truant, Thomas Fekete
    Pages 169-175
  10. Christopher V. Plowe, Thomas E. Wellems
    Pages 197-209
  11. Bruno J. Bromke, Merewyn C. Furiga, Russell C. Hendershot, Michelle McGinn
    Pages 211-216
  12. John R. Graybill
    Pages 217-234
  13. Back Matter
    Pages 235-248

About this book


Development and Implications of Antimicrobial Resistance One of the most ominous trends in the field of antimicrobial chemotherapy over the past decade has been the increasing pace of development of antimicrobial resistance among microbial pathogens. The hypothesis that man can discover a magic bullet to always cure a particular infection has proved false. Physicians are now seeing and treating patients for which there are few therapeutic alternatives, and in some cases, none at all. Until recently there was little concern that physicians might be losing the war in our ability to compete with the evolving resistance patterns of microbial pathogens. Now the general public is very aware of the threat to them if they become infected, thanks to cover story articles in major magazines such as Time, Newsweek, newspapers, and other news sources. Antimicrobial resistance is not a novel problem. Shortly after the widespread introduction of penicillin in the early 1940s, the first strains of penicillin-resistant staphylococci were described. Today it is an uncommon event for a clinical laboratory to isolate an S. aureus that is sensitive to penicillin. Other gram-positive strains of bacteria have become resistant, including the exquisitely sensitive Streptococcus pneumoniae. Sensitivity to vancomycin was once so uniform that it was used in routine clinical laboratories as a surrogate marker for whether an organism should be classified as a gram-positive. That criterion can no longer be relied upon because of emerging resistance among some species. Gram-negative bacteria, viruses, fungi, and parasites all have succeeded in developing resistance.


antibiotics assessment bacteria development fungi health health care immunodeficiency infection infections malaria parasite research resistance virus

Editors and affiliations

  • Donald L. Jungkind
    • 1
  • Joel E. Mortensen
    • 2
  • Henry S. Fraimow
    • 3
  • Gary B. Calandra
    • 4
  1. 1.Thomas Jefferson University HospitalPhiladelphiaUSA
  2. 2.St. Christopher’s Hospital for ChildrenPhiladelphiaUSA
  3. 3.The Graduate HospitalPhiladelphiaUSA
  4. 4.Merck Research LaboratoriesWest PointUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1995
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-9205-8
  • Online ISBN 978-1-4757-9203-4
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals