© 1994


Molecular Biology, Clinical Aspects

  • Michael E. Maragoudakis
  • Pietro M. Gullino
  • Peter I. Lelkes

Part of the NATO ASI Series book series (NSSA, volume 263)

Table of contents

  1. Front Matter
    Pages i-x
  2. Embryonic Development and Angiogenesis

    1. Françoise Dieterlen-Lièvre, Dominique Luton, Luc Pardanaud
      Pages 1-8
    2. Peter I. Lelkes, Vangelis G. Manolopoulos, Dawn Chick, Brian R. Unsworth
      Pages 15-28
  3. Molecular Biology of Angiogenesis

    1. Marco Presta, Marco Rusnati, Anna Gualandris, Patrizia Dell’Era, Chiara Urbinati, Daniela Coltrini et al.
      Pages 39-50
    2. D. S. Grant, D. Morales, M. C. Cid, H. K. Kleinman
      Pages 51-60
    3. Domenico Maglione, Maria Graziella Persico
      Pages 73-80
    4. M. Ziche, L. Morbidelli, L. Mantelli, E. Masini, F. Ledda, H. J. Granger et al.
      Pages 91-96
    5. Mahmoud Ragab, Periasamy Selvaraj, Demetrios S. Sgoutas
      Pages 103-109
    6. Theodosia A. Kalfa, Mary E. Gerritsen, Effie C. Tsilibary
      Pages 111-118
    7. Aristidis Charonis, Nitsa Koliakos, George Koliakos, Gregg Fields, Lorrel Regger, Carrie Lynch et al.
      Pages 119-123
  4. Regulation of Angiogenesis

    1. M. E. Maragoudakis, N. E. Tsopanoglou, G. C. Haralabopoulos, E. Sakkoula, E. Pipili-Synetos, E. Missirlis
      Pages 125-134
    2. Hynda K. Kleinman, Derrick S. Grant, Maura C. Kibbey
      Pages 135-141
    3. Michael S. Pepper, Jean-Dominique Vassalli, Lelio Orci, Roberto Montesano
      Pages 149-170

About this book


Angiogenesis is a multistep process, which involves activation, proliferation and directed migration of endothelial cells to form new capillaries from existing vessels. Under physiological conditions, in the adult organisms angiogenesis is extremely slow, yet it can be activated for a limited time only in situations such as ovulation or wound healing. In a number of disease states, however, there is a derangement of angiogenesis, which can contribute to the pathology of these conditions. Hence, understanding the molecular biology of endothelial cell activation and differentiation and the mechanisms involved in the regulation of angiogenesis, could explain the derangement in disease states and also provide the basis for developing promoters or suppressors of angiogenesis for clinical applications. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis: Molecular Biology, Oinical Aspects" held in Rhodes, Greece, from June 16-27, 1993. This meeting was a comprehensive review of the various aspects of angiogenesis such as embryonic development, endothelial cell heterogeneity and tissue specificity, molecular biology of endothelial cell, mechanisms for the regulation of angiogenesis, disease states in which angiogenesis is involved and potential application of promoters or suppressors of angiogenesis. The presentations and discussions of the meeting provided an opportunity for investigators from many different areas of basic science and medicine to exchange information, evaluate the present status and provide future research directions in the field of angiogenesis.


Embryo Promoter biology development growth migration molecular biology proliferation protein research tissue

Editors and affiliations

  • Michael E. Maragoudakis
    • 1
  • Pietro M. Gullino
    • 2
  • Peter I. Lelkes
    • 3
  1. 1.University of Patras Medical SchoolPatrasGreece
  2. 2.University of Torino Medical SchoolTorinoItaly
  3. 3.University of Wisconsin Medical SchoolMilwaukeeUSA

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