Scientific and Clinical Applications of Magnetic Carriers

  • Urs Häfeli
  • Wolfgang Schütt
  • Joachim Teller
  • Maciej Zborowski

Table of contents

  1. Front Matter
    Pages i-xv
  2. The Mystery and History of Magnetism

    1. Urs Häfeli
      Pages 1-10
  3. Preparation and Modification of Biodegradable Magnetic Particles

    1. Wenche S. Prestvik, Arvid Berge, Preben C. Mørk, Per M. Stenstad, John Ugelstad
      Pages 11-35
    2. Shlomo Margel, Sigalit Gura, Hanna Bamnolker, Boaz Nitzan, Tami Tennenbaum, Beni Bar-Toov et al.
      Pages 37-51
    3. Cordula Grüttner, Joachim Teller, Wolfgang Schütt, Fritz Westphal, Carl Schümichen, Bernd-R. Paulke
      Pages 53-67
    4. Bernd-R. Paulke, Norbert Buske, Supandi Winoto-Morbach
      Pages 69-76
    5. B. Hertzog, T. Mottl, D. Yim, E. Mathiowitz
      Pages 77-92
    6. Detlef Müller-Schulte, Frank Füssl, Marcel De Cuyper
      Pages 93-107
    7. W. Schüppel, R. Müller, C. Ulbrich, H. Steinmetz
      Pages 109-115
    8. M. P. Pileni, N. Feltin, N. Moumen
      Pages 117-133
  4. Characterization of Magnetic Particles

    1. Rainer H. Müller, Martin Lück, Stephan Harnisch, Kai Thode
      Pages 135-148
    2. Stine-Kathrein Kraeft, Urs O. Häfeli, Lan Bo Chen
      Pages 149-161
    3. Wolfgang Schütt, Cordula Grüttner, Bernd Paulke, Phil Goetz, Nobuya Hashimoto
      Pages 163-170
    4. Maria de Fatima Da Silva, François Gendron, Jean Claude Bacri, Jacky Roger, Jean-Noël Pons, Michel Robineau et al.
      Pages 171-176
    5. Olga M. Mykhaylyk, Oleg N. Razumov, Alexandre K. Dudchenko, Yuri V. Pankratov, Eduard K. Dobrinsky, Vladimir N. Sosnitsky et al.
      Pages 177-204
  5. Applications in Cell Separation and Analysis

    1. Maciej Zborowski
      Pages 205-231
    2. Maciej Zborowski, Lee R. Moore, Liping Sun, Jeffrey J. Chalmers
      Pages 247-260
  6. Applications in Molecular Biology

    1. Marie Bosnes, Arne Deggerdal, Anne Rian, Lars Korsnes, Frank Larsen
      Pages 269-285
    2. Takeshi Sano, Gabriel Reznik, Sandor Vajda, Charles R. Cantor, Cassandra L. Smith
      Pages 295-301
    3. Susanne Bierbaum, Holger Notbohm
      Pages 311-322
  7. Biomedical Applications of Magnetic Carriers

    1. Michael A. Vladimirsky, Victor I. Philippov, Anatoly A. Kuznetsov, Alexander I. Polozov, Edward K. Dobrinsky
      Pages 353-357
    2. Steffen Mitzner, Jan Stange, Jens Freytag, Piotr Peszynski, Stefan Aldinger, Ursula Kaben et al.
      Pages 359-369
    3. Anatoly A. Kuznetsov, Avetik R. Harutyunyan, Edward K. Dobrinsky, Victor I. Filippov, Andrei G. Malenkov, Anatoly F. Vanin et al.
      Pages 379-389
    4. Michael V. Kutushov, Anatoly A. Kuznetsov, Victor I. Filippov, Oleg A. Kuznetsov
      Pages 391-397
    5. Avraham Halbreich, Jacky Roger, Jean-Noël Pons, Maria de Fatima Da Silva, Eric Hasmonay, Michel Roudier et al.
      Pages 399-417
    6. Wilfried Andrä, Klaus Eitner, Rudolf Hergt, Matthias Zeisberger
      Pages 419-427
    7. Oleg A. Kuznetsov, Karl H. Hasenstein
      Pages 429-444
  8. Drug Delivery and Radionuclide Therapy

    1. Sharon K. Pulfer, James M. Gallo
      Pages 445-455
    2. Larry M. Allen, Thomas Kent, Christina Wolfe, Clara Ficco, Jacqueline Johnson
      Pages 481-494
    3. Sanat Ya. Makhmudov, Anatoly A. Kuznetsov, Victor I. Filippov
      Pages 495-499
    4. Urs O. Häfeli, Gayle J. Pauer, William K. Roberts, John L. Humm, Roger M. Macklis
      Pages 501-516
    5. Detlef Müller-Schulte, Frank Füssl, Heiko Lueken, Marcel De Cuyper
      Pages 517-526
  9. MRI-Contrast Agents

    1. Jeff W. M. Bulte, Rodney A. Brooks
      Pages 527-543
    2. Mayk Kresse, Susanne Wagner, Matthias Taupitz
      Pages 545-559
    3. Sabine Päuser, Regina Reszka, Susanne Wagner, Karl-Jürgen Wolf, Heinz Johannes Buhr, Gerd Berger
      Pages 561-568
  10. Hyperthermia

    1. A. Jordan, P. Wust, R. Scholz, H. Faehling, J. Krause, R. Felix
      Pages 569-595
    2. Jean-Claude Bacri, Maria de Fatima Da Silva, Régine Perzynski, Jean-Noël Pons, Jacky Roger, Domagoj Sabolovic’ et al.
      Pages 597-606
  11. Back Matter
    Pages 619-628

About this book


The discovery of uniform latex particles by polymer chemists of the Dow Chemical Company nearly 50 years ago opened up new exciting fields for scientists and physicians and established many new biomedical applications. Many in vitro diagnostic tests such as the latex agglutination tests, analytical cell and phagocytosis tests have since become rou­ tine. They were all developed on the basis of small particles bound to biological active molecules and fluorescent and radioactive markers. Further developments are ongoing, with the focus now shifted to applications of polymer particles in the controlled and di­ rected transport of drugs in living systems. Four important factors make microspheres interesting for in vivo applications: First, biocompatible polymer particles can be used to transport known amounts of drug and re­ lease them in a controlled fashion. Second, particles can be made of materials which bio­ degrade in living organisms without doing any harm. Third, particles with modified surfaces are able to avoid rapid capture by the reticuloendothelial system and therefore en­ hance their blood circulation time. Fourth, combining particles with specific molecules may allow organ-directed targeting.


biomedical application biomedical applications endothelium imaging living systems

Editors and affiliations

  • Urs Häfeli
    • 1
  • Wolfgang Schütt
    • 2
  • Joachim Teller
    • 3
  • Maciej Zborowski
    • 1
  1. 1.The Cleveland Clinic FoundationClevelandUSA
  2. 2.University of RostockRostockGermany
  3. 3.micro capsRostockGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1997
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4419-3283-9
  • Online ISBN 978-1-4757-6482-6
  • Buy this book on publisher's site
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