Mechanisms of Lymphocyte Activation and Immune Regulation II

  • Sudhir Gupta
  • William E. Paul

Table of contents

  1. Front Matter
    Pages 1-10
  2. T Cell Receptors and T Cell Activation

    1. Front Matter
      Pages 11-11
    2. Mark M. Davis, Pamela J. Bjorkman
      Pages 13-16
    3. Michael B. Brenner, Frans Hochstenbach, Hamid Band, Christina Parker, Joanne McLean, Shingo Hata et al.
      Pages 17-19
    4. Richard D. Klausner, Allan M. Weissman, Michal Baniyash, Juan S. Bonifacino, Lawrence E. Samelson
      Pages 21-24
    5. Mark A. Goldsmith, Linda K. Bockenstedt, Paul Dazin, Arthur Weiss
      Pages 25-33
    6. Sudhir Gupta, Makito Shimizu, Renu Batra, Bharathi Vayuvegula
      Pages 35-42
  3. Interleukin 1 and Interleukin 2 Receptors

    1. Front Matter
      Pages 43-43
    2. Charles A. Dinarello, Scott F. Orencole, Nerina Savage
      Pages 45-53
    3. Warner C. Greene, Ernst Böhnlein, Miriam Siekevitz, Dean W. Ballard, B. Robert Franza, John W. Lowenthal
      Pages 55-60
  4. B Lymphocyte Development and B Cell Activation

    1. Front Matter
      Pages 67-67
    2. Jeffrey M. Gimble, Shin-Ichi Hayashi, Carolynn E. Pietrangeli, Grace Lee, Paul W. Kincade
      Pages 69-75
    3. Skye McDougall, Suzanne Eaton, Craig L. Peterson, Kathryn Calame
      Pages 77-86
    4. Fritz Melchers, Steven R. Bauer, Christoph Berger, Hajime Karasuyama, Akira Kudo, Antonius Rolink et al.
      Pages 87-93
    5. G. G. B. Klaus, M. M. Harnett, K. P. Rigley
      Pages 95-100
    6. Jeffrey B. Sutro, Bharathi S. Vayuvegula, Sudhir Gupta, Michael D. Cahalan
      Pages 113-122
  5. Interleukins and B Lymphocyte Activation

    1. Front Matter
      Pages 123-123
    2. Eva Severinson, Hee-Bom Moon, Susanne Bergstedt-Lindqvist, Ulla Persson, Christoph Heusser, Janet Stavnezer
      Pages 125-133
    3. Tadamitsu Kishimoto, Tetsuya Taga, Katsuhiko Yamasaki, Tadashi Matsuda, Bo Tang, Atsushi Muraguchi et al.
      Pages 135-143
    4. John H. Kehrl, Anthony S. Fauci
      Pages 145-154
  6. Back Matter
    Pages 155-158

About this book


The ac ti vati on of Iymphocytes by physiologie ligands has become a central area of study for immunologists. Furthermore, Iymphocytes offer many advantages for the study of general aspects of receptor-mediated cellular activation. For these reasons, research on the cellular and molecular aspects of the activation of Iymphocytes by antigens, antigen analogues, Iymphokines and other growth factors has expanded enormously in the last several years. Aseries of conferences, "The International Conferences on Lymphocyte Activation", has been initiated to meet the growing need for a forum for the discussion of the topics that are included within the area of Iymphocyte activation. This volume represents the proceedings of the Second International Conference on Lymphocyte Activation and Immune Regulation, held on February 18-20, 1988 at Newport Beach, California. The proceedings comprise four major sections. The first deals with the T cell receptors and T cell activation. It includes a model for the T cell receptor interaction with a complex of MHC plus antigen, structure of y c'i T cell receptor and their distinct isotypic forms, the role of zeta chain in the expression and structure of T cell receptors and its role in transmembrane signalling. The use of somatic cell mutants in the study of signal transduction function of the T cell antigen receptors and the early and late steps of signal transduction via a / ß T cell antigen receptors are discussed.


T cell antibody antigen cytokine growth factor immunoglobulin lymphocytes physiology

Editors and affiliations

  • Sudhir Gupta
    • 1
  • William E. Paul
    • 2
  1. 1.Division of Basic and Clinical ImmunologyUniversity of California, IrvineIrvineUSA
  2. 2.National Institute of Allergy and Infectious Diseases National Institutes of HealthBethesdaUSA

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