© 1990


  • Herman Friedman
  • T. W. Klein
  • Masayasu Nakano
  • Alois Nowotny

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Synthesis, Structure and Function

    1. Front Matter
      Pages 1-1
    2. S. Kusumoto, N. Kusunose, M. Imoto, T. Kamikawa, T. Shiba
      Pages 3-11
    3. H. Mayer, J. H. Krauss, A. Yokota, J. Weckesser
      Pages 45-70
    4. N. Kasai, S. Arata, J. Mashimo, T. Hirayama, M. Ueno
      Pages 71-79
    5. E. Th. Rietschel, L. Brade, U. Schade, U. Seydel, U. Zähringer, K. Brandenburg et al.
      Pages 81-99
    6. E. V. Vinogradov, W. Kaca, Y. A. Knirel, A. Rozalski, K. Kotelko, N. K. Kochetkov
      Pages 127-130
    7. G. M. Zdorovenko, S. N. Veremeychenko, I. Ya. Zakharova, Yu. A. Knirel
      Pages 131-135
    8. M. Ohta, N. Kido, K. Jann, Y. Arakawa, T. Komatsu, H. Ito et al.
      Pages 137-139
    9. N. Kido, M. Ohta, H. Ito, K-I. Iida, Y. Arakawa, T. Komatsu et al.
      Pages 141-145
  3. Active Sites, Contaminants, Qualitative and Quantitative Assays

    1. Front Matter
      Pages 147-147
    2. Yu. S. Ovodov, T. F. Solovjeva, V. A. Khomenko, O. D. Novikova, G. M. Frolova, I. M. Yermak et al.
      Pages 185-187
    3. A. M. Municio, S. Abarca, J. L. Carrascosa, R. Garcia, I. Diaz-Laviada, M. J. Ainaga et al.
      Pages 199-202

About this book


This volume is based on the proceedings of the International Symposium on Bacterial Endotoxins held in Japan. May 11-14. 1988 and sponsored by the International Endotoxin Society and the International Society for Immuno­ pharmacology. Speakers and participants of this symposium provided new information concerning fundamental and clinical aspects of endotoxin research conducted over the last half decade or so. Advances have been made in understanding the structure and nature of endotoxin molecules and their effects on a wide variety of both cellular and subcellular aspects, of immunity. metabolism and physiology. both in vivo and in vitro. Endotoxins are constituents of gram negative bacteria. Since their original discovery in the nineteenth century. many laboratories studied their chemical composition. their physico- and immunochemica1 properties. as well as their pharmacological and physiological effects on the host. Much is now known about the chemical structure of the endotoxins. There is also a grow­ ing body of information concerning the multiple effects of endotoxins on the host including immune mechanisms. Some effects have been found to be benefi­ cial to the host and endotoxins are being used more frequently to induce important mediators of immunity as well as increasing resistance against infections by many microorganisms as well as inhibiting growth of tumors in experimental animal models and in man.


bacteria immunity infection infections pharmacology physiology resistance

Editors and affiliations

  • Herman Friedman
    • 1
  • T. W. Klein
    • 1
  • Masayasu Nakano
    • 2
  • Alois Nowotny
    • 3
  1. 1.The University of South FloridaTampaUSA
  2. 2.Jichi Medical SchoolTochigi-KenJapan
  3. 3.University of PennsylvaniaPhiladelphiaUSA

Bibliographic information

  • Book Title Endotoxin
  • Editors H. Friedman
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Springer-Verlag US 1990
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-306-43241-5
  • Softcover ISBN 978-1-4757-5142-0
  • eBook ISBN 978-1-4757-5140-6
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages XVII, 715
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Immunology
  • Buy this book on publisher's site
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