Molecular Diagnostics

For the Clinical Laboratorian

  • William B. Coleman
  • Gregory J. Tsongalis

Part of the Pathology and Laboratory Medicine book series (PLM)

Table of contents

  1. Front Matter
    Pages i-x
  2. Basic Molecular Biology

    1. Front Matter
      Pages 1-1
    2. R. Keith Esch
      Pages 35-60
  3. Molecular Technologies

    1. Front Matter
      Pages 61-61
    2. Sharon Collins Presnell
      Pages 63-87
    3. David H. Sorscher
      Pages 89-101
    4. Robert B. Sisk
      Pages 103-121
    5. Elizabeth M. Rohlfs, W. Edward Highsmith Jr.
      Pages 123-162
    6. Jeffrey S. Bartlett
      Pages 193-214
  4. Applications to Molecular Pathology

    1. Front Matter
      Pages 215-215
    2. Gregory J. Tsongalis
      Pages 217-228
    3. Myra J. Wick, Pamela A. Crifasi, Zhenyuan Wang, Stephen N. Thibodeau
      Pages 229-248
    4. Bruce F. Bower, Carl D. Malchoff
      Pages 249-269
    5. John H. Contois, Juch Chin Huang
      Pages 271-291
    6. William B. Coleman, Gregory J. Tsongalis
      Pages 293-316
    7. William N. Rezuke, Evelyn C. Abernathy
      Pages 317-339
  5. Issues for the Clinical Molecular Pathology Laboratory

    1. Front Matter
      Pages 361-361
    2. Lawrence M. Silverman
      Pages 373-378
  6. Back Matter
    Pages 379-390

About this book


In Molecular Diagnostics For the Clinical Laboratorian notable practitioners describe how laboratory medicine is practiced today and illuminate how it will function tomorrow as the revolutionary advances afforded by molecular diagnostics become increasingly central to effective analysis. Proceeding from a discussion of elementary nucleic acid technology to a review of the more advanced techniques, the distinguished contributors lay the groundwork for a comprehensive understanding of their applications throughout clinical medicine. The result is a detailed description of those molecular technologies currently used in diagnostic laboratories, as well as those that seem particularly promising. Detailed discussions of specific clinical applications include those for cancer, hematological malignancies, cardiovascular disease, and neuromuscular, endocrine, and infectious diseases.
Molecular Diagnostics For the Clinical Laboratorian captures for active physicians and clinical laboratory scientists a practical sense of the rapidly evolving applications of molecular biology now being introduced to the medical community at record speeds. Presenting this powerful new technology in a concise, readily understandable fashion, this book constitutes the premier tutorial guide to today's molecular diagnostic techniques.


DNA PCR biology cancer diagnostics gene expression gene therapy genes genetics infectious diseases molecular biology molecular genetics molecular mechanisms mutation nucleic acid

Editors and affiliations

  • William B. Coleman
    • 1
  • Gregory J. Tsongalis
    • 2
  1. 1.Department of Pathology and Laboratory MedicineUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Department of Pathology and Laboratory MedicineHartford HospitalHartfordUSA

Bibliographic information

Industry Sectors
Health & Hospitals