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Biology of Growth Factors

Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications

  • Jeffrey E. Kudlow
  • David H. MacLennan
  • Alan Bernstein
  • Avrum I. Gotlieb

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 234)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Perspectives on the Control of Growth and Differentiation

  3. Growth Factor — Oncogene Relationships

    1. Tony Pawson, Peter Greer, Michael Moran, Kelly Meckling-Hansen, Angela Brooks-Wilson, Ivan Sadowski
      Pages 55-64
    2. Paul T. Jubinsky, Yee-Guide Yeung, Rosalba Sacca, Wei Li, E. Richard Stanley
      Pages 75-90
  4. Receptor Transducing Mechanisms

    1. Gordon N. Gill, Michael G. Rosenfeld, William S. Chen, Paul J. Bertics, Cheri S. Lazar
      Pages 91-103
    2. Jeffrey E. Kudlow, Jeffrey D. Bjorge, Michael S. Kobrin, Andrew J. Paterson
      Pages 105-126
    3. Gerard M. Housey, Mark D. Johnson, W. L. Wendy Hsiao, Catherine A. O’Brian, I. Bernard Weinstein
      Pages 127-140
    4. Mark A. Goldsmith, Arthur Weiss
      Pages 195-211
    5. J. J. M. Bergeron, W. H. Lai, D. G. Kay, J. J. Doherty II, M. N. Khan, B. I. Posner
      Pages 213-224
    6. Yan C. Kwok, Cecil C. Yip
      Pages 225-233
  5. Back Matter
    Pages 235-238

About this book

Introduction

Growth factors are elaborated to control the growth of cells in such physiological processes as wound healing, tissue regeneration and the immune response. Abnormal production of these growth factors, their receptors or intracellular med!ators of their action may lead to disease states including oncogenesis. This volume will focus on exciting developments in defining the precise molecular lesions that permit the conversion of controlled proliferative signals to neoplasia, on the possible involvement of growth factors in the development of blood vessel diseases as seen in diabetes and atherosclerosis, on the altered immune surveillance that leads to autoimmunity and on the fundamental mechanisms by which growth factors signal their target cells. We expect that the contents of this volume will help promote understanding of the role of these fundamental biological processes and their alterations in a wide variety of disease states and stimulate new investi­ gations in this important area of biomedical research. The Editors v CONTENTS PERSPECTIVES ON THE CONTROL OF GROWTH AND DIFFERENTIATION Perspectives on the Biology of Growth Factors . . . •. . . . . . . . . . . . . . . • I. B. Fritz Platelet-Derived Growth Factor- Its Role in Health and Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 R. Ross and E. W. Raines Molecular and Developmental Biology Aspects of Fibroblast Growth Factor. • . . . . . . . . . . . . . . • . . . . . . . . . • • . . . . . . . . . . . . . . . . . . • 23 D. Gospodarowicz Chemical and Biochemical Properties of Human Angiogenin. . . . . . . . . . 41 B. L. Vallee and J. F. Riordan GROWTH FACTOR - ONCOGENE RELATIONSHIPS Structure - Function Relationships in Cellular and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases. . . . . . . . . . . . . . . . . . . . . . . . 55 T. Pawson. P. Greer, M. Moran, K.

Keywords

biology molecular biology oncogene protein receptor

Editors and affiliations

  • Jeffrey E. Kudlow
    • 1
  • David H. MacLennan
    • 2
  • Alan Bernstein
    • 3
  • Avrum I. Gotlieb
    • 4
  1. 1.Department of Clinical Biochemistry and Medicine and Banting and Best Diabetes CentreUniversity of Toronto General HospitalTorontoCanada
  2. 2.Banting and Best Department of Medical ResearchUniversity of TorontoTorontoCanada
  3. 3.Department of Medical Genetics and Medical BiophysicsUniversity of Toronto and Division of Molecular and Developmental Biology Mount Sinai Hospital Research InstituteTorontoCanada
  4. 4.Department of Pathology and Banting and Best Diabetes CentreUniversity of Toronto and Toronto General Hospital General HospitalTorontoCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-1980-2
  • Copyright Information Springer Science+Business Media New York 1988
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-1982-6
  • Online ISBN 978-1-4757-1980-2
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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