The Togaviridae and Flaviviridae

  • Sondra Schlesinger
  • Milton J. Schlesinger

Part of the The Viruses book series (VIRS)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Stephen C. Harrison
    Pages 21-34
  3. Ellen G. Strauss, James H. Strauss
    Pages 35-90
  4. Margaret Kielian, Ari Helenius
    Pages 91-119
  5. Milton J. Schlesinger, Sondra Schlesinger
    Pages 121-148
  6. Sondra Schlesinger, Barbara G. Weiss
    Pages 149-169
  7. Dennis T. Brown, Lynn D. Condreay
    Pages 171-207
  8. Diane E. Griffin
    Pages 209-249
  9. Charles M. Rice, Ellen G. Strauss, James H. Strauss
    Pages 279-326
  10. Margo A. Brinton
    Pages 327-374
  11. Thomas P. Monath
    Pages 375-440
  12. Back Matter
    Pages 441-453

About this book


The publication of this volume of The Viruses entitled The Togaviridae and Flaviviridae comes at an appropriate time. The structure and rep­ lication strategies of these viruses are now known to be sufficiently di­ verse to warrant the removal of flaviviruses from the Togaviridae family and establish them as an independent family. Flaviviridae have a special place in the history of virology. The prototype virus-yellow fever virus­ was the first virus to be identified as the cause of a human disease. Some of the history of this discovery is described in Chapter 1 of this volume; in Chapter 10 the complete sequence of the RNA genome of the virus is presented. This sequence not only defines the primary structure of the viral proteins, it also clarifies the mechanism of translation of the fla­ vivirus genome. Knowledge of the sequence of the structural proteins of these viruses represents an important step in the potential goal of using purified flavivirus glycoproteins as vaccines. Many of the chapters in this volume focus on the structure and replication of the Togaviridae. These viruses have provided valuable models for studies in cell biology, partic­ ularly with regard to the cotranslational and posttranslational steps re­ quired for the synthesis and localization of membrane glycoproteins. Fur­ thermore, Togaviridae have been pivotal in our growing understanding of how enveloped viruses enter and exit from cells. The broad outlines of the structure and gene expression of Togavir­ idae and Flaviviridae are known, but important questions remain.


Antigen Organe Pathogene Polypeptide Translation Virus arbovirus infection infections plasma membrane temperature transcription vaccine

Editors and affiliations

  • Sondra Schlesinger
    • 1
  • Milton J. Schlesinger
    • 1
  1. 1.Department of Microbiology and ImmunologyWashington University School of MedicineSt. LouisUSA

Bibliographic information

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