Purine Metabolism in Man-IV

1. Purine Metabolism in Normal Lymphoid Cells

   1. Changes in Purine Salvage Pathway Enzyme Activities During Human Lymphocyte Differentiation Induced by Thymosin Fraction 5

      • Morton J. Cowan, Mark Fraga, Arthur J. Ammann

      Pages 93-98

   2. Purine Metabolism in Human Thymocyte Subsets: Relevance for Lymphocytic Differentiation

      • H. J. Schuurman, J. P. R. M. van Laarhoven, R. Broekhuizen, P. Brekelmans, G. Th. Spierenburg, C. G. Figdor et al.

      Pages 99-106

   3. Purine Metabolism in Splenocytes and Thymocytes of Various Mammalian Species

      • G. J. Peters, A. Oosterhof, J. H. Veerkamp

      Pages 107-110

   4. Purine Interconversion Pathways in T, B, Tγ and T-Tγ Cells from Human Peripheral Blood

      • J. P. R. M. van Laarhoven, G. Th. Spierenburg, H. Collet, G. Delespesse, C. H. M. M. De Bruyn

      Pages 111-118

   5. Metabolism of Guanosine and Deoxyguanosine in Mammalian Lymphocytes and their Influence on Mitogenic Stimulation

      • G. J. Peters, A. Oosterhof, J. H. Veerkamp

      Pages 119-124

   6. Concentration of Nucleotides in Peripheral Blood Lymphocytes of Various Mammalian Species

      • R. A. De Abreu, G. J. Peters, J. H. Veerkamp

      Pages 125-128

   7. Plasma Membrane 5′-Nucleotidase and other Purine Enzymes in Murine Lymphocytes

      • N. Lawrence Edwards, Beverly S. Mitchell, I. H. Fox, J. J. Mond

      Pages 129-132

2. Purine Metabolism in Relation to Lymphocyte Function

   1. Biochemical Basis for Lymphocyte Dysfunction in Adenosine Deaminase and Purine Nucleoside Phosphorylase Deficiencies

      • Dennis A. Carson, Donald B. Wasson, Ellen Lakow, Naoyuki Kamatani

      Pages 133-139

   2. Absence of Lymphocyte Ecto-5′-Nucleotidase in Infants with Reticuloendotheliosis and Immunodeficiency

      • E. W. Gelfand, C. P. Rao, D. McCurdy, N. H. Sigal, A. Cohen

      Pages 141-146

   3. Regulation of Human Lymphoblast Ecto-5′-Nucleotidase by Zinc

      • R. B. Pilz, R. C. Willis, S. Wanlass, J. E. Seegmiller

      Pages 147-152

   4. Decreased T Cell Ecto-5′-Nucleotidase Activity in Agammaglobulinemia Patients is Not Due to Altered Proportions of Helper and Suppressor T Cells as Defined by the Monoclonal Antibodies Okt4 and Okt8

      • Linda F. Thompson, Robert I. Fox

      Pages 153-158

   5. Metabolic Findings in a Patient with Adenosine Deaminase Deficiency and Severe Combined Immunodeficiency

      • Erminia De Carapella-Luca, Michele Stegagno, Paola Lucarelli, Armando Signoretti, Carlo Imperato, Sybe K. Wadman et al.

      Pages 159-162

   6. Purine Metabolism in Intact Cells from a Purine Nucleoside Phosphorylase Deficient Child

      • A. Cohen, J. Barankiewicz, A. Issekutz, E. W. Gelfand

      Pages 163-166

   7. Inosine Formation from Hypoxanthine by Intact Erythrocytes and Fibroblasts of an Immunodeficient Child with Purine Nucleoside Phosphorylase Deficiency

      • L. D. Fairbanks, D. R. Webster, H. A. Simmonds, C. F. Potter, A. R. Watson

      Pages 167-170

   8. Mononuclear Cells in S-Phase in a Patient with Purine Nucleoside Phosphorylase Deficiency

      • G. T. Rijkers, B. J. M. Zegers, L. J. M. Spaapen, D. H. Rutgers, W. Kuis, J. J. Roord et al.

      Pages 171-174

   9. Involvement of Dietary Nucleotides in T Lymphocyte Function

      • Frederick B. Rudolph, Anil D. Kulkarni, Vicky B. Schandle, Charles T. Van Buren

      Pages 175-178

   10. Nucleotide Levels in Peripheral Blood Mononuclear Cells of Immunodeficient Children: Problems of Measurement

       • A. Goday, D. R. Webster, H. A. Simmonds, R. J. Levinsky, D. Perrett, Z. Brown et al.

       Pages 179-182

3. Immunopharmacology

   1. Inhibition of Murine Suppressor T Cell Development by 2′-Deoxyguanosine in Vivo

      • Th. W. van den Akker, A. T. J. Bianchi, H. Bril, R. Benner

      Pages 183-188

   2. Biochemical and Immunological Evaluation of Long Term Coformycin Administration in the Mouse

      • Trevor Lukey, Floyd F. Snyder

      Pages 189-192

   3. Increased Incidence of Homogeneous Immunoglobulins in Irradiated, Reconstituted Mice After Prolonged Treatment with 2′-Deoxyguanosine

      • Th. W. van den Akker, G. Ziere, A. P. Gillen, J. Radl, R. Benner

      Pages 193-197

These two volumes, entitled "Purine Metabolism in Man IV" con­ tain the papers presented at the Fourth International Symposium on Human Purine and Pyrimidine Metabolism", held in Maastricht (The Netherlands), June 1982. The proceedings of the three previous meet­ ings in Tel Aviv (Israel, 1973), Baden (Austria, 1976) and Madrid (Spain, 1979) were also published by Plenum Press. In the past few years interest in purine and pyrimidine metabo­ lism under normal and pathological conditions has been growing rapid­ ly. Apart from the more or less classical topics such as hyperuricae­ mia, clinical gout and urolithiasis, an increasing number of papers relating to other fields have been presented at successive meetings. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse­ quences for other types of cancer. At previous meetings there have been pointers implicating purine metabolism in relation to normal cardiac and skeletal muscle function. During the present meeting mych new data on both issues have been re­ ported which indicate clear differences in the pathways of ATP metabo­ lism. The widening of the field of interest is also illustrated by the recent work on infectious disease: exploitation of the differences in purine metabolic pathways in certain parasites compared with those in human cells has resulted in new rationales for therapy being devel­ oped.

• ATP
• Nucleotide
• Purine
• Pyrimidine
• amino acid
• base
• enzyme
• enzymes
• metabolism
• methylation
• mitochondria
• pharmacology
• phosphorylation
• primary structure
• translation

• University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands

  Chris H. M. M. Bruyn

• Guy’s Hospital Medical School, London, UK

  H. Anne Simmonds

• University of Vienna, Vienna, Austria

  Mathias M. Müller

Policies and ethics