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Immunological Adjuvants and Vaccines

  • Gregory Gregoriadis
  • Anthony C. Allison
  • George Poste

Part of the NATO ASI Series book series (NSSA, volume 179)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Howard M. Grey, Søren Buus, Alessandro Sette
    Pages 13-20
  3. R. Bomford
    Pages 43-46
  4. H. Snippe, C. A. Kraaijeveld
    Pages 47-59
  5. Ernst Th. Rietschel, Lore Brade, Ulrich Schade, Ulrich Seydel, Ulrich Zähringer, Harald Loppnow et al.
    Pages 61-74
  6. J. H. L. Playfair, A. W. Heath, J. B. De Souza
    Pages 75-78
  7. Gregory Gregoriadis, Lloyd Tan, Qifu Xiao
    Pages 79-94
  8. Nico van Rooijen, Donghui Su
    Pages 95-106
  9. H. Snippe, A. F. M. Verheul, J. E. G. van Dam
    Pages 107-122
  10. Carl R. Alving, Robert L. Richards, Michael D. Hayre, Wayne T. Hockmeyer, Robert A. Wirtz
    Pages 123-131
  11. Robert L. Hunter, Beth Bennett, Devery Howerton, Steve Buynitzky, Irene J. Check
    Pages 133-144
  12. B. Morein, K. Lövgren, S. Höglund
    Pages 153-161
  13. Ruth Arnon
    Pages 175-185
  14. Back Matter
    Pages 233-244

About this book

Introduction

Vaccination, chiefly responsible for the eradication of smallpox and the control of poliomyelitis and German measles in man and of foot-and­ mouth, Marek's and Newcastle disease in domestic animals, remains the best answer to infectious diseases. Early vaccines were live wild type organ­ isms but these have been largely replaced by attenuated or killed organisms or by purified components (subunits) thereof. More recently, developments in recombinant DNA techniques, the advent of monoclonal antibodies and progress in our understanding of the immunological structure of proteins, have laid the foundations for a new generation of vaccines. For instance, subuni t vaccines have been produced through gene cloning and a number of peptides mimicking small regions of proteins on the outer coat of viruses and capable of eliciting virus neutralizing antibodies, have been synthes­ ized. Such vaccines are defined at the molecular level, can elicit immune responses controlling specific infectious organisms and are, thus, potent­ ially free of the problems inherent in conventional ones. However, because subunit and peptide vaccines are only weakly or non-immunogenic, they re­ quire the presence of immunological adjuvants. These are a diverse array of agents that promote specific humoural and/or cell-mediated immunity responses to antigens. This book contains the proceedings of the 1st NATO Advanced Studies Institute "Immunological Adjuvants and Vaccines" held in Cape Sounion Beach, Greece during 24 June-5 July, 1988.

Keywords

Antigen DNA gene expression infectious disease interferon proteins

Editors and affiliations

  • Gregory Gregoriadis
    • 1
  • Anthony C. Allison
    • 2
  • George Poste
    • 3
  1. 1.Royal Free Hospital School of MedicineLondonUK
  2. 2.Syntex ResearchPalo AltoUSA
  3. 3.Smith Kline French LaboratoriesPhiladelphiaUSA

Bibliographic information

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